SYNTHESIS AND ASSESSMENT OF ANTI-CANCER AND ANTI-ANGIOGENIC ACTIVITY OF FUSARAOC

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 Fusarochromanone（FC-101 a）是一种由真菌木贼镰刀菌（Fusarium equiseti）产生的类黄酮。Lee等人首先通过NMR和质谱法分离并确定了这种分子的结构（没有立体化学）。FC-101 a与其他已知的色满酮天然产物的区别在于沿着其上表面交替的<$-酮基-胺官能团和在C（2）处的两个偕甲基的独特排列。根据Cahn-Inglold-Prelog惯例，C（3 '）处的绝对立体化学定义为3'-R。侧链对于分子的生物活性是重要的（如下所述）。例如，C（3 '）胺的乙酰化会大大降低该分子在生物学研究中的效力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Fusarochromanone (FC-101a) is a flavonoid produced by the mold, Fusarium equiseti. Lee et al. first isolated and determined the structure of this molecule (without stereochemistry) via NMR and mass spectrometry. FC-101a is distinguished from other known chromanone natural products by the unique arrangement of the alternating ¿-keto-amine functionality along its upper face and the two geminal methyl groups at C(2). The absolute stereochemistry at C(3') is defined as 3'-R, according to the Cahn-Inglold-Prelog convention. The side chain, is important to the molecule's biological activity (described below). Acetylation of the C(3') amine, for example, drastically reduces the molecule's potency in biological studies.