Towards a better understanding of the effect of the pentafluorosulfanyl group on the lipophilicity and acid/base properties of alcohols and amines

更好地了解五氟硫基对醇和胺的亲脂性和酸/碱性质的影响

• 批准号: 571856-2021
• 负责人: Paquin, JeanFrançoisJF
• 金额: $ 1.82万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748630
• 关键词: Towards; better; understanding; effect; pentafluorosulfanyl

This project aims to gain a better understanding of the effect of the pentafluorosulfanyl group on the lipophilicity and acid/base properties of alcohols and amines. In this international collaboration, Prof. Jean-François Paquin from Université Laval (Canada) propose to team up with Prof. Bruno Linclau from Ghent University (Belgium) to tackle this endeavour. Prof. Paquin's research group focuses on synthetic organofluorine chemistry with a particular expertise in the synthesis of SF5-containing compounds while Prof. Linclau's research is focused on investigating how fluorination of organic compounds can modify their physical properties, with a focus on hydrogen bonding, lipophilicity, and conformation. This collaboration brings together two highly regarded research groups in their respective field to work on a project that could lead to very impactful discoveries in drug discovery.

该项目旨在更好地了解五氟硫烷基对醇和胺的亲油性和酸/碱性质的影响。在这项国际合作中，来自加拿大拉瓦尔大学的Jean-François Paquin教授提议与比利时根特大学的Bruno Linclau教授合作开展这项工作。Paquin教授的研究小组专注于合成有机氟化学，特别擅长合成含SF 5的化合物，而Linclau教授的研究重点是研究有机化合物的结构如何改变其物理性质，重点是氢键，亲脂性和构象。这项合作汇集了两个在各自领域备受推崇的研究小组，致力于一个可能导致药物发现方面非常有影响力的发现的项目。