Clinical

临床核心（核心C）形成了临床、翻译和基于患者样本的中心联系 跨学科的艾滋病毒研究由宾夕法尼亚大学CFAR研究人员进行。其中心目标是提供基本的， 来自多个项目的翻译，临床，流行病学和行为科学研究人员 学科快速获得广泛的流行病学数据和艾滋病毒感染者的临床材料 个人的详细特征，以及识别艾滋病毒感染者招募到 横向或纵向研究。为了支持这一使命，临床中心提供CFAR 研究人员： (1)成人/青少年数据库由宾夕法尼亚大学附属成人医院护理的近3000名患者组成 四家医院的艾滋病毒实践和一家青少年（行为感染）实践，以及儿科数据库 包括275例围产期感染儿童的纵向数据;（2）成人/青少年和儿科标本 与数据库链接的储存库，（3）向研究者提供新鲜患者材料的能力， 包括通过静脉切开术或单采血液成分术收集的大量细胞、生殖器分泌物、胃肠道分泌物 淋巴组织和周围脂肪组织活检，和脑脊液;和（4）使用实验室 支持临床标本的处理、储存和运输。此外，临床核心（5） 为学员和初级教员提供指导结构。 在即将到来的资金周期，我们计划扩大这些服务，以进一步支持CFAR调查员 需求成人/青少年数据库将扩大至包括4000名受试者。重点招聘 将进行纳入样本库的受试者，以扩大患者材料的数量 从具有特定临床表型的艾滋病毒感染者，包括急性疾病，有效控制 在没有治疗的情况下的病毒复制，高病毒载量的治疗，病毒学失败，双嗜性或 R5+X4病毒的混合物和肝炎合并感染。未感染艾滋病毒的人从事高危行为 将被招募参加一项新的计划，重点是艾滋病毒传播的生物学。将花费精力 增加跨学科研究的投资组合，重点是妇女的健康问题，艾滋病毒的生物学 胃肠道感染，以及与开发有效疫苗有关的科学。的 将每年对临床中心提供的服务进行评估，以确保满足研究者的需求 并且使资源的利用最大化。

The Clinical Core (Core C) forms the central nexus of clinical, translational and patient sample-based interdisciplinary HIV research conducted by Penn CFAR investigators. Its central objective is to offer basic, translational, clinical, epidemiologic, and behavioral science investigators from multiple programmatic disciplines quick access to a broad range of epidemiologic data and clinical material from HIV infected individuals characterized in detail, as well as the identification of HIV infected individuals for recruitment into cross sectional or longitudinal studies. In support of this mission the Clinical Core provides CFAR investigators with: (1) an Adult/Adolescent Database comprised of nearly 3000 patients cared for at Penn-affiliated adult HIV practices at four hospitals and one adolescent (behaviorally infected) practice, and a Pediatric Database including longitudinal data on 275 perinatally infected children; (2) Adult/Adolescent and Pediatric Specimen Repositories linked to the Databases, (3) the capability to supply investigators with fresh patient material, including large volumes of cells collected by phlebotomy or apheresis, genital secretions, gastrointestinal lymph tissue and peripheral adiopose tissue biopsies, and cerebrospinal fluid; and (4) the use of laboratory support for the processing, storage, and shipment of clinical specimens. In addition, the Clinical Core (5) provides a mentoring structure for trainees and junior faculty. In the coming funding cycle we plan to expand these services to further support CFAR investigator needs. The Adult/Adolescent Database will be enlarged to include 4000 subjects. A focused recruitment of subjects for inclusion in the Specimen Repository will be conducted to expand the volume of patient material from HIV infected individuals with specific clinical phenotypes, including acute illness, effective control of virus replication in the absence of therapy, high viral loads off therapy, virologic failure, dual-tropic or mixtures of R5+X4 virus, and hepatitis coinfection. HIV uninfected individuals engaged in high risk behaviors will be recruited for a new initiative concentrating on the biology of HIV transmission. Effort will be expended to augment the portfolio of interdisciplinary research focused on women's health issues, the biology of HIV infection in the gastrointestinal tract, and science related to the development of an effective vaccine. The services provided by the Clinical Core will be evaluated annually to ensure that investigators' needs are met and utilization of the resources is maximized.