Philadelphia HIV Therapeutics and Prevention Clinical Trials Unit

描述(由申请人提供)：费城艾滋病毒治疗和预防临床试验股(Philadelphia HIV CTU-PHCTU)将提供行政基础设施和科学领导，通过四个具体的研究目标，在五个拟议的艾滋病毒研究网络、成人治疗学、儿科和孕产妇人口的治疗学、综合预防、疫苗和杀微生物剂中促进艾滋病毒治疗和预防的科学研究：具体目标1.通过委员会和方案小组成员以及发起新的网络科学，参与艾滋病毒研究网络科学议程的创建和实施。具体目标2.通过具有成本效益的临床试验，参与执行艾滋病毒研究网络的科学议程。具体目标3.培训和指导下一代艾滋病毒调查员。通过邀请研究员和初级教员参与方案制定、教育会议和临床试验，PHCTU将积极招募和培训下一代艾滋病毒调查人员。具体目标4.教育费城医学界、科学界和受艾滋病毒影响的社区了解艾滋病毒治疗和预防方面的进展。费城艾滋病毒CTU将帮助协调和宣传现有的与艾滋病毒有关的医疗和科学论坛，并将继续通过其社区咨询委员会和通过对艾滋病毒受影响群体的教育宣传，寻求受艾滋病毒影响社区的投入。费城艾滋病毒CTU将建立一个综合、高效的临床试验结构，包括四个临床研究地点，三个在宾夕法尼亚大学(宾夕法尼亚大学佩雷尔曼医学院-PSOM和费城儿童医院-CHOP)医学院校园，一个在德雷克塞尔大学医学院校园，包括两个专注于成人艾滋病毒治疗试验的网站，一个 这将专注于成人预防试验，并将重点放在涉及儿童广告青少年人口的试验上。 相关性：尽管在了解艾滋病毒发病机制、实现有效的抗逆转录病毒疗法(ART)和扩大艾滋病毒预防战略的范围方面取得了许多进展，但在艾滋病毒治疗和预防领域仍然存在许多挑战，需要在成人、青少年和儿科人群中进行研究。

DESCRIPTION (provided by applicant): The Philadelphia HIV Therapeutic and Prevention Clinical Trials Unit (Philadelphia HIV CTU-PHCTU) will provide the administrative infrastructure and scientific leadership to advance the science of HIV treatment and prevention within the five proposed HIV Research Networks, Adult Therapeutics, Therapeutics in Pediatric and Maternal Populations, Integrated Prevention, Vaccines, and Microbicides through four specific research aims: Specific Aim 1. Participate in the creation and implementation of the scientific agenda of the HIV Research Networks through committee and protocol team membership and through initiation of new Network science. Specific Aim 2. Participate in the implementation of the scientific agenda of the HIV Research Networks through the cost efficient conduct of clinical trials. Specific Aim 3. Train and mentor the next generation of HIV investigators. By engaging fellows and junior faculty in protocol development, educational conferences and clinical trials, the PHCTU will actively recruit and train the next generation of HIV investigators. Specific Aim 4. Educate the Philadelphia medical, scientific and HIV-affected communities about advances in HIV therapy and prevention. The Philadelphia HIV CTU will help to coordinate and advertise the HIV-related medical and scientific forums that currently exist, and will continue to seek input from the HIV-affected community through its Community Advisory Board and through educational outreach to HIV affected groups. The Philadelphia HIV CTU will feature an integrated, efficient clinical trials structure with four clinical research sites, three on the University of Pennsylvania (University of Pennsylvania Perelman School of Medicine-PSOM and The Children's Hospital of Philadelphia- CHOP) medical campus and one on the Drexel University medical campus, including two sites that will focus on adult HIV therapeutic trials, one that will focus on adult prevention trials, and one that will focus on trials involving pediatric ad adolescent populations. RELEVANCE: Despite numerous advances in the understanding of HIV pathogenesis, the realization of effective antiretroviral therapy (ART), and the widening scope of HIV prevention strategies, many challenges remain in the domains of HIV treatment and prevention that will need to be studied in adult, adolescent, and pediatric populations.