International

核心一的具体目标是：1）教育，培训和指导来自博茨瓦纳和宾夕法尼亚州的研究人员 对全球卫生研究感兴趣; 2）提高对艾滋病毒/艾滋病及其并发症的认识， 博茨瓦纳进行高质量的流行病学和以病人为导向的研究。Penn开发了 博茨瓦纳强大的临床和教育计划，主要基于PEPFAR资金， 我们研究的临床基础核心提供以下服务：i）为宾夕法尼亚大学的研究人员提供咨询 为博茨瓦纳拟议的研究提供可行性; ii）对研究护士进行现场监督， ㈢协助卫生部、博茨瓦纳医院和宾夕法尼亚大学的知情同意; ㈣ 收集和处理样本，以便进行测试、储存或运输; v）提供办公场所和互联网， （六）为宾夕法尼亚大学的调查人员在博茨瓦纳工作期间提供住房;以及（七）确定 博茨瓦纳大学和卫生部的合作者与宾夕法尼亚大学的科学家合作， 这符合我们在国家建立研究能力的目标。在过去的四年里，我们帮助 博茨瓦纳大学获得有史以来第一个NIH资助;宾夕法尼亚大学CFAR研究人员获得6 CFAR 博茨瓦纳研究的发展赠款;宾夕法尼亚大学的科学家获得了2项多丽丝杜克基金会奖， 包括5年的医学生研究奖学金;我们获得了盖茨-默克基金会 为博茨瓦纳卫生保健工作者的艾滋病毒/结核病教育、预防和治疗提供资金。目前 该中心正在博茨瓦纳支持19项研究。 在下一个资金周期，我们将通过建设扩大我们的研究办公室和实验室基础设施 与卫生部和博茨瓦纳大学医学院合作建造一座大楼; 我们将扩大我们在机会性感染、艾滋病和结核病合并感染、坚持治疗等领域的研究议程， 艾滋病毒感染妇女的治疗、艾滋病毒预防和宫颈癌。 核心I增强了宾夕法尼亚大学和博茨瓦纳研究人员进行高质量全球卫生研究的能力 这是解决与博茨瓦纳公民有关的问题的研究。

The Specific Aims of Core I are: 1) To educate, train and mentor investigators from Botswana and Penn interested in global health research; and 2) To advance knowledge about HIV/AIDS and its complications in Botswana by performing high quality epidemiologic and patient-oriented research. Penn has developed strong clinical and educational programs in Botswana based primarily on PEPFAR funding, which provides the clinical base for our research. The Core provides the following services: i) Advising Penn investigators on the feasibility of studies proposed for Botswana; ii) Providing on-site supervision of research nurses and technicians; iii) Assisting with informed consent at the Ministry of Health, Botswana hospitals and Penn; iv) Collecting and processing samples for testing, storage or shipping; v) Providing office space and Internet for Core personnel; vi) Providing housing for Penn investigators while working in Botswana; and vii) Identifying collaborators at the University of Botswana and the Ministry of Health to work with Penn scientists, which is consistent with our goal of building research capacity in country. During the past 4 years, we helped the University of Botswana get its first-ever NIH grant; Penn CFAR investigators obtained 6 CFAR Developmental Grants for studies in Botswana; Penn scientists obtained 2 Doris Duke Foundation Awards, including a 5-year medical student research fellowship grant; and we obtained Gates-Merck Foundation funding for HIV-TB education, prevention and treatment of health care workers in Botswana. Currently, the Core is supporting 19 studies in Botswana. In the next funding cycle we will expand our research office and laboratory infrastrucute through construction of a building in collaboration with the Ministry of Health and the University of Botswana School of Medicine; we will expand our research agenda in the areas of opportunistic infections, HIV-TB co-infections, adherence to therapy, HIV prevention, and cervical cancer in HIV infected women. Core I has enhanced the capabilities of Penn and Botswana investigators to do high quality global health research that is addressing issues that are relevant to the citizens of Botswana.