COBRE: RIH: THEME B: PATHOGENESIS OF GI TUMORS, GERD, ESOPHAGITIS, SUBTITLE:

COBRE：RIH：主题 B：胃肠道肿瘤、胃食管反流病、食管炎的发病机制，副标题：

• 批准号: 7960509
• 负责人: WEIBIAO CAO
• 金额: $ 14.67万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-10 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960509
• 关键词: Acids; Barrett Esophagus; Cells; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Development; Esophageal Adenocarcinoma; Esophagitis; Exposure to; Funding; Gastroesophageal reflux disease; Gastrointestinal Neoplasms; Grant; Inflammatory; Institution; Metaplastic Cell; NCI Center for Cancer Research; Pathogenesis; Reactive Oxygen Species; Research; Research Personnel; Resources; Source; United States National Institutes of Health; cytokine; research and development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will hypothesize that the release of reactive oxygen species (ROS) and proinflammatory cytokines from inflammatory cells and/or metaplastic cells of Barrett's esophagus (BE) following exposure to acid exposure promotes the development of esophageal adenocarcinoma(EA).

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本项目将假设暴露于酸暴露后Barrett食管（BE）的炎症细胞和/或化生细胞释放活性氧（ROS）和促炎细胞因子促进食管腺癌（EA）的发展。