COBRE: RIH: THEME B: PATHOGENESIS OF GI TUMORS, GERD, ESOPHAGITIS, SUBTITLE:

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本项目将假设暴露于酸暴露后，巴雷特食管（BE）的炎症细胞和/或化生细胞释放活性氧（ROS）和促炎细胞因子促进了食管腺癌（EA）的发展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will hypothesize that the release of reactive oxygen species (ROS) and proinflammatory cytokines from inflammatory cells and/or metaplastic cells of Barrett's esophagus (BE) following exposure to acid exposure promotes the development of esophageal adenocarcinoma(EA).