Virology

病毒学

• 批准号: 7685030
• 负责人: JOHN Christopher KAPPES
• 金额: $ 18.6万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-15 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7685030
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Arts; Biological Assay; Cell Line; Clinical; Consultations; Containment; Development; Engineering; Ensure; Environment; Equipment; Faculty; Fee-for-Service Plans; Fostering; Goals; Grant; HIV; Human Resources; Immunologics; Immunology; Knowledge; Laboratories; Life; Methods; Mission; Molecular; Molecular Biology; Nature; Operative Surgical Procedures; Pathogenesis; Phase; Plasmids; Policies; Proteins; Quality Control; Reagent; Recombinant Proteins; Recombinants; Research; Research Personnel; Resources; Safety; Services; Site; Strategic Planning; Structure; Supervision; Techniques; Technology Transfer; Training; Training and Education; Vaccine Research; Viral; Viral Vector; Work; base; cost; experience; gene cloning; genetically modified cells; laboratory facility; multidisciplinary; programs; protein expression; safety practice; success; tool; virology; virus culture

The goals of the VC are to enable, broaden and enhance HIV/AIDS research by providing state-of-the-art BSL-2-3 laboratory facilities and equipment, experienced and dedicated professional staff, education, training, virology-specific research materials and assays and protein expression capabilities, all to support multidisciplinary, investigator-initiated basic and clinical HIV/AIDS research. Each of our specific aims represent significant value-added to HIV/AIDS research and the overall CFAR mission as they (i) enable live HIV research among all UAB investigators, (ii) foster the development of HIV/AIDS research by new investigators, (iii) broaden the research capabilities among CFAR faculty, and (iv) encourage research that is translational and multidisciplinary in nature. The services of VC are integral to the AIDS Center as they provide critical support to numerous multidisciplinary basic and clinical HIV/AIDS research programs. The specific aims for the VC are as follows: 1. To provide and maintain state-of-the-art BSL 2-3 laboratory facilities that are necessary to conduct "live" HIV research. 2. To provide safety education and training, and ongoing supervision for all faculty and staff that work in the BSL 2-3 Laboratory. 3. To augment AIDS research capabilities through consultation, assay-specific training, and provision of standardized assays and defined molecular and virologic reagents. 4. To develop specialized genetically engineered tools and assays, including cell lines and viral vectors, to help address new and important investigative challenges in HIV/AIDS research. 5. To continue to offer CFAR investigators the molecular biology services, reagents, and training, that allow a rapid progression from cloning of genes to structure and/or function studies of the gene product. This renewal application reflects important changes that have occurred in the academic HIV/AIDS environment nationally and at UAB since this grant was last competitively renewed. The critical services of two cores that were previously operated independently, the Central Virus Culture Core and the Molecular Biology Core, have been combined into a single core that is now referred to as the Virology Core (VC). This strategy is based on similarities in the nature of virology services offered by the two previous cores and is meant to ensure that we are able to retain and continue to provide critical value-added services, while maximizing proficient utilization of precious CFAR resources.

VC的目标是通过提供最先进的BSL-2-3来实现、扩大和加强艾滋病毒/艾滋病研究