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Role of Inflammation in the Development and Progression of Pancreatic Cancer

Role of Inflammation in the Development and Progression of Pancreatic Cancer
炎症在胰腺癌发生和进展中的作用
批准号：
7966177
负责人：
Syed Hussain
金额：
$21.76万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7966177
关键词：
ApoptosisBreastCancer PatientCell Cycle ArrestChronicColonContractsDNA RepairDataDevelopmentDiseaseFamilyFreezingGene ExpressionGenesGenetic PolymorphismGoalsGrowthHeadHumanIL8 geneImmuneImmune responseIn VitroInflammationInflammatoryInflammatory ResponseInheritedInterleukin-6LungMalignant NeoplasmsMalignant neoplasm of liverMalignant neoplasm of pancreasMarylandMediatingMediator of activation proteinMicroRNAsMigration Inhibitory FactorModelingMolecularMolecular ProfilingNOS2A geneNeoplastic Cell TransformationNitric OxidePancreasPancreatic Ductal AdenocarcinomaPancreatitisParaffinPathway interactionsPatientsPhosphorylationPhosphotransferasesPlayPolymerase Chain ReactionPrevention therapyProstateProteinsRNARegulationReportingResourcesRiskRoleSamplingSeveritiesStaining methodStainsTechniquesTestingTimeTumor BiologyTumor Necrosis Factor-alphaTumorigenicityUbiquitinationUniversitiescytokinehuman TNF proteinoutcome forecastpancreatic neoplasmphenylpyruvate tautomerasetranscription factortumor

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中文摘要
翻译
我们启动了这个项目，并从25对冷冻的胰腺导管腺癌(PDAC)样本和周围的非肿瘤性胰腺组织以及通过NCI-马里兰大学资源合同收集的3个正常胰腺组织中提取了RNA。这些RNA样本正在进行分析，以确定一组25个炎症基因的实时聚合酶链式反应技术的表达。用免疫组织化学方法检测同一样本的石蜡切片中NOS2、磷酸化FoxO、MIF和磷酸化Akt的表达。
英文摘要
We have started this project and isolated RNA from 25 pairs of snap-frozen pancreatic ductal adenocarcinoma (PDAC) samples and the surrounding non-tumorous pancreas from the same patients and 3 normal pancreas from non-cancer donors that have been collected through the NCI-University of Maryland Resource Contract. These RNA samples are being analyzed to determine the expression of a set of 25 inflammatory genes with real-time polymerase chain reaction technique. Paraffin sections of the same sample set are being examined for the expression of NOS2, phospho-FoxO, MIF and phospho-Akt by immunohistochemical staining.
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会议论文
Animal model of Pancreatic Cancer
Molecular Profiling of Pancreatic Cancer
Role of Immune and Inflammation Mediators in Progression of Pancreatic Cancer
Forkhead-box (FOX) Transcription Factors in the Progression of Pancreatic Cancer
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