Molecular Profiling of Pancreatic Cancer

在过去的六个月里，在接受终身教职跟踪调查员的职位后，我一直在实验室里建立一个胰腺癌研究项目。我们启动了25例胰腺导管腺癌(PDAC)标本和来自具有流行病学特征的患者的非肿瘤胰腺组织和来自NCI-马里兰大学资源合同收集的3例正常胰腺组织的大规模mRNA和microRNA(MiRNA)表达分析。我们还从德国的合作者那里获得了一套40个PDAC样本。在我们的研究中，这两组样本被用作测试和验证队列，以确定疾病的新生物标记物。我们目前正在准备一份方案和问卷，以启动大巴尔的摩地区胰腺癌的病例对照研究。

In last six months, after assuming the tenure track investigator position, I have been working on establishing a pancreatic cancer research program in the laboratory. We have initiated the large-scale mRNA and microRNA (miRNA) expression analysis of 25 pancreatic ductal adenocarcinoma (PDAC) samples and paired surrounding non-tumorous pancreas from the patients with epidemiological profile and 3 normal pancreas from non-cancer donors that have been collected through the NCI-University of Maryland Resource Contract. We also have obtained a set of 40 PDAC samples from collaborators in Germany. The two sets of samples are being used as test and validation cohorts in our studies to identify novel biomarkers for the disease. We are currently preparing a protocol and questionnaire to initiate the case-control study of pancreatic cancer in the greater Baltimore area.