Mechanism and effect of exenatide on weight loss: Randomized controlled trial

志愿者将接受筛选并入住我们的住院临床研究单位。他们将在整个房间的间接热量计中进行葡萄糖耐量、食物摄入和能量消耗的基线测量。随机分配至活性药物或安慰剂组后，将重复这些测量。基线入院后，志愿者将作为门诊患者接受随访，最初每周一次（持续一个月），随后每月一次，持续5个月。然后，志愿者将再次入院，重复测量食物摄入量。 然后，所有志愿者都可以选择开放标签使用艾塞那肽另外6个月，在此期间，他们将再次每月随访一次。 该研究目前正在招募志愿者。 迄今出版物：无

Volunteers will be screened and admitted to our inpatient clinical research unit. They will undergo baseline measurements of glucose tolerance, food intake and energy expenditure in a whole room indirect calorimeter. After randomization to active drug or placebo, these measurements will be repeated. After the baseline admission, volunteers will be followed as outpatients initially on a weekly basis (for one month), followed by a monthly basis for another 5 months. Volunteers will then be readmitted for repeat measurements of food intake. All volunteers will then have the option of open label use of exenatide for another 6 months during which time they will again be followed monthly. The study is currently recruiting volunteers. Publications to date: None