Nutrient Absorption in Lean Versus Obese Individuals

这项研究考察了两种标准饮食(卡路里含量不同)的肥胖者和瘦肉者以及大便和尿液能量损失，以比较瘦人和肥胖者的这些值。这项研究还在调查粪便中特定的常量营养素含量，以检验这些参数在瘦人和肥胖者之间的差异。这些测量的可重复性也在一小部分人身上进行测试。与圣路易斯华盛顿大学的Jeffrey Gordons博士实验室合作，将送出粪便样本以确定粪便细菌菌群系统类型，以检查粪便能量损失和肠道菌群数量之间的关系。 最初的14名瘦身者和9名肥胖者的初步结果没有显示出大便或尿液能量损失的任何差异。两组的大便卡路里范围都很大，从2%到9%不等。每种饮食的大便卡路里损失在每个个体中都是相关的。在高卡路里饮食中，肥胖者的粪便卡路里损失(因此吸收的食物较少)比瘦肉者更多。初步结果显示，肠道细菌随着营养负荷的增加而急剧变化。

This study examines obese and lean individuals on two standard diets (which differ by calorie content) and the stool and urine energy losses to compare these values in lean versus obese individuals. The study is also investigating the specific macronutrient content of stool to examine differences in these parameters between lean and obese individuals. The repeatability of these measurements is also being tested in a subset of individuals. In collaboration with Dr. Jeffrey Gordons lab at Washington University in St. Louis, samples of stool will be sent for determination of the fecal bacterial flora phylotypes to examine the association between stool energy loss and enteric flora populations. Preliminary results from an initial 14 lean and 9 obese individuals failed to show any difference in stool or urine energy loss. The range of calories stool was large, varying from 2 to 9 % in both groups. Stool calorie loss on each diet was associated in each individual. On the higher calorie diet, obese individuals had greater stool calorie loss (so absorbed less food ) than lean. Preliminary results show acute changes in gut bacteria with nutrient load.