Development of the treatment for acute coronary syndrome by dental bacteria elimination

在174例急性冠状动脉综合征（ACS）患者的冠状动脉血和动脉粥样硬化斑块中，检出牙龈卟啉单胞菌（P.gingivalis）DNA的比例为58%。此外，牙龈蛋白酶（一种来自细菌的蛋白酶）的活性在牙菌斑中增加。虽然我们推测PD治疗可以预防ACS的蛋白酶诱导的斑块破裂，从而减少主要不良心脏事件，但在平均14.8个月的预后研究中，样本中细菌的检测对ACS发病后6个月的事件发生率没有影响。

In 174 patients with acute coronary syndrome (ACS), the DNA of P. gingivalis, which is a representative responsible bacterium for periodontal disease (PD), was detected in 58% of the sample including the coronary artery blood and the atherosclerotic plaque. Moreover, the activity of Gingipain, which is a protease from the bacterium, increased in the plaque. Although we speculated that the treatment of PD can prevent the protease-induced plaque rupture for ACS and thereby reduce the major adverse cardiac event, the detection of the bacterium in the sample did not influence to the event rate at 6 months after the onset of ACS in the prognosis research for average 14.8 months.