Development of the treatment for acute coronary syndrome by dental bacteria elimination

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In 174 patients with acute coronary syndrome (ACS), the DNA of P. gingivalis, which is a representative responsible bacterium for periodontal disease (PD), was detected in 58% of the sample including the coronary artery blood and the atherosclerotic plaque. Moreover, the activity of Gingipain, which is a protease from the bacterium, increased in the plaque. Although we speculated that the treatment of PD can prevent the protease-induced plaque rupture for ACS and thereby reduce the major adverse cardiac event, the detection of the bacterium in the sample did not influence to the event rate at 6 months after the onset of ACS in the prognosis research for average 14.8 months.