Chile Fetal Alcohol Study

智利胎儿酒精研究

• 批准号: 7968711
• 负责人: James Mills
• 金额: $ 31.56万
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7968711
• 关键词: 11-dehydro-thromboxane B2; Adverse effects; Age; Alcohol abuse; Alcohol-Related Neurological Defects; Alcohols; Categories; Child; Chile; Classification; Data; Data Set; Defect; Eicosanoids; Exposure to; Eye; Eye Abnormalities; Fetal Alcohol Spectrum Disorder; Fetal Alcohol Syndrome; Fetus; Heavy Drinking; Home visitation; Hormones; House Call; Injury; Life; Link; Measures; Mothers; National Institute of Child Health and Human Development; Neural Conduction; Only Child; Ophthalmic examination and evaluation; Outcome; Oxidative Stress; Pathogenesis; Pattern; Population; Pregnancy; Prospective Studies; Prostaglandins; Recording of previous events; Refractory; Reporting; Research Design; Risk; Role; Screening procedure; Universities; Vasoconstrictor Agents; Vasodilator Agents; Visual Acuity; Woman; alcohol exposure; alcohol measurement; base; drinking; experience; fetal; high risk; in utero; interest; isoprostaglandin F2alpha type-III; malformation; offspring; pregnant; prenatal; prostaglandin F1; urinary; vasoconstriction

To date this study has shown that children exposed to large quantities of alcohol in utero have abnormal nerve conduction velocities despite not having classic fetal alcohol syndrome. The study has also shown that the risk of ophthalmologic abnormalities is limited to those who have fetal alcohol syndrome; other heavily exposed children did not have a excess of eye defects. The study has completed the classification of all exposed subjects into categories that define the adverse effects that they have experienced. Subjects can now be analyzed based on the categories of classic fetal alcohol syndrome (FAS) or fetal alcohol spectrum disorder or alcohol related neurological defects. This will make it possible to link outcomes in exposed children to data on alcohol exposure collected during their prenatal life.

到目前为止，这项研究表明，尽管没有典型的胎儿酒精综合症，但在宫内暴露于大量酒精的儿童有异常的神经传导速度。这项研究还表明，眼科异常的风险仅限于患有胎儿酒精综合征的人；其他严重接触酒精的儿童没有过多的眼睛缺陷。这项研究已经完成了对所有接触过的受试者的分类，这些类别定义了他们所经历的不良影响。受试者现在可以根据典型的胎儿酒精综合症(FAS)或胎儿酒精谱系障碍或与酒精相关的神经缺陷的类别进行分析。这将有可能将接触酒精的儿童的结局与他们产前生活中收集的酒精暴露数据联系起来。