Chile Fetal Alcohol Study

智利胎儿酒精研究

• 批准号: 8351195
• 负责人: James Mills
• 金额: $ 32.4万
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8351195
• 关键词: Alcohol abuse; Alcohol consumption; Alcohols; Child; Chile; Data; Exposure to; Eye Abnormalities; Fetal Alcohol Exposure; Fetal Alcohol Syndrome; Fetus; Goals; Growth; Heavy Drinking; Home visitation; Hormones; House Call; Investigation; Life; Mothers; National Institute of Child Health and Human Development; Neural Conduction; Outcome; Oxidative Stress; Pattern; Population; Pregnancy; Premature Birth; Prospective Studies; Reporting; Research Design; Risk; Screening procedure; Universities; Woman; alcohol consumption during pregnancy; alcohol effect; base; drinking; experience; fetal; in utero; offspring; pregnant; prenatal; stillbirth; tool

Our study design enabled us to identify and follow 96 women consuming at least 4 drinks/day during pregnancy. In these women with heavy prenatal alcohol use, there were three stillbirths and one preterm delivery; 98 matched nondrinking women had no stillbirths and two preterm births. Preterm rates did not differ significantly. The stillbirth rate was higher in the exposed group (p = 0.06). Additional investigation showed the stillbirth rate in the exposed population (3.1%) was significantly higher (p = 0.019) than the reported Chilean population rate (0.45%). Our data suggest that heavy alcohol consumption may increase the risk for stillbirth but not preterm delivery. Analysis is now complete and a report has been prepared describing the outcomes of the exposed children based on the amount and pattern of maternal alcohol consumption during pregnancy. The data will be reported soon.

我们的研究设计使我们能够识别和跟踪96名妇女在怀孕期间每天至少喝4杯饮料。在这些产前大量饮酒的妇女中，有三名死胎和一名早产; 98名匹配的非饮酒妇女没有死胎和两名早产。早产率无显著差异。接触组的死胎率较高（p = 0.06）。进一步调查显示，接触人群的死产率（3.1%）明显高于（p = 0.019）报告的智利人口死产率（0.45%）。我们的数据表明，大量饮酒可能会增加死胎的风险，但不会增加早产的风险。 分析现已完成，并编写了一份报告，根据母亲怀孕期间饮酒的数量和模式，说明受影响儿童的结果。 数据将很快公布。