Indiana PROSPECT

描述（由申请人提供）：印第安纳州前景建立在全国最大、最复杂的健康信息交换基础上，该交换已包含超过1000万患者的25亿结构化观察结果和3800万文本文档。该资源已用于各种临床结果和临床有效性研究。根据我们对基础设施差距的分析以及通过作为前景的一部分进行特定CER研究获得的经验，我们将增强该基础设施，以捕获更丰富的临床数据，特别是增强我们纳入患者结局的能力，改善器械使用数据的捕获，纳入基因组和其他高通量结果的能力，先进的技术，以识别患者的招募和登记技术。为了证明这个环境的可用性，并告知其进一步的发展，我们建议进行一个新的CER项目评估治疗阿尔茨海默氏症。CER研究将评估阿尔茨海默病行为症状的药物治疗。阿尔茨海默病已被确定为CER优先级的第一四分位数。因为我们的方法是基于人口的，我们将纳入一个重要的少数民族人口。该应用程序代表了Regenstrief Institute，Inc（健康信息技术的世界领先者）的医学信息学计划与两个印第安纳州大学研究计划之间的合作：衰老研究中心和临床药理学部门。这些方案在与服务不足人口有关的研究方面有着既定的记录。因此，该申请结合了相当多的调查人员，环境和研究优势，继续建立一个新的CER基础设施，以支持国家的证据CER优先事项。我们将在我们既定的治理方法基础上，测试和改进共享这些研究数据库和财务模型的方法，以实现基于所创造价值的可持续发展。 公共卫生相关性：该提案旨在加强印第安纳州中部现有的信息技术基础设施，以提高国家进行比较有效性研究（CER）的能力，并将这些新能力应用于评估阿尔茨海默病治疗的新型CER项目。

DESCRIPTION (provided by applicant): The Indiana PROSPECT builds on the nation's largest, most sophisticated health information exchange that already contains over 2.5 billion structured observations and 38 million text documents for over 10 million patients. This resource is already used for a variety of clinical outcomes and clinical effectiveness research. Based on our analysis of gaps in the infrastructure and experience gained by conducting a specific CER study as part of the PROSPECT, we will enhance this infrastructure to capture richer clinical data and particularly enhance our ability to incorporate patient outcomes, improved capture of device utilization data, capabilities to incorporate genomic and other high throughput results, advanced technologies to identify patient for recruitment and enrollment technologies. In order to demonstrate the usability of this environment and to inform its further development, we propose to conduct a novel CER project evaluating treatment for Alzheimer's. The CER study will evaluate of medication treatment for behavioral symptoms of Alzheimer's disease. Alzheimer's disease has been identified as a first quartile CER priority. Because our approach is population based, we will incorporate a significant minority population. This application represents collaboration between the Medical Informatics Program at the Regenstrief Institute, Inc (a world leader in health information technology) and two Indiana University research programs: the Center for Aging Research and the Division of Clinical Pharmacology. These programs have an established track record in research relevant to under-served populations. Thus, this application combines considerable investigator, environment, and research strengths to continue to build a novel CER infrastructure in support of the nation's evidentiary CER priorities. We will build on our established governance approach to test and improve approaches for sharing access to these research databases and financial models for sustainability based on value created. PUBLIC HEALTH RELEVANCE: Project Narrative This proposal seeks to enhance the existing information technology infrastructure in Central Indiana to improve the nation's capacity to conduct comparative effectiveness research (CER) and apply these new capacities to a novel CER project evaluating treatment for Alzheimer's disease.