Early Intervention in Pulmonary Exacerbation in CF
CF 肺部病情加重的早期干预
基本信息
- 批准号:7946288
- 负责人:
- 金额:$ 80.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-27 至 2015-06-30
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdherenceAdolescentAdultAnxietyArtsCaringChronic Obstructive Airway DiseaseClinicalClinical TrialsCoughingCystic FibrosisDataData CollectionDiagnosisDyspneaEarly identificationEarly treatmentEmergency SituationEnrollmentEquationEquipmentEthnic OriginFailureForced expiratory volume functionGenderGoalsHome environmentHospitalizationImpairmentIndividualInfectionInterventionLifeLungLung diseasesMeasuresMental DepressionModelingMonitorOutcomeOutcome MeasurePatientsPlaguePrincipal InvestigatorPulmonary Cystic FibrosisPulmonary Function Test/Forced Expiratory Volume 1Quality of lifeQuestionnairesRecoveryRecurrenceReportingRespiratory FailureRespiratory physiologySeverity of illnessSocial supportSocioeconomic StatusSpirometrySymptomsTimebasecare deliverycare seekingclinical carecomputerizeddata exchangedepressive symptomshealth related quality of lifeimprovedmortalitynovel strategiesprimary outcomeprogramspublic health relevancepulmonary functionrespiratorystandardized caresuccesstelehealthtreatment as usual
项目摘要
DESCRIPTION (provided by applicant): Individuals with cystic fibrosis (CF) are plagued by daily respiratory symptoms such as cough and dyspnea. In spite of dramatic improvements in care, their lives are greatly shortened due to progressive respiratory failure. The course of CF is marked by recurrent pulmonary exacerbations characterized by worsened symptoms and declines in pulmonary function. CF acute pulmonary exacerbations result in more rapid decline in lung function and increased. Preliminary data from our groups suggest that delays in seeking care are associated with lack of recovery of lung function after an exacerbation. The primary goal of this proposal is to perform a clinical trial to determine the efficacy of early intervention in the treatment of adolescent and adult CF acute pulmonary exacerbation. The study will assess the integration of two novel approaches to the treatment of CF pulmonary exacerbation: 1) the use of home spirometers to identify and trigger treatment of an exacerbation; and 2) the use of home based assessment of patient symptoms to identify and trigger the treatment of a pulmonary exacerbation, both integrated into one protocolized care plan. This novel approach will be compared to usual care with the primary outcome measure being lung function as measured with forced expiratory volume in the first second (FEV1). We hypothesize that if pulmonary exacerbations are treated earlier with a multi-faceted intervention, the progression of lung disease will be slowed. This approach will utilize state of the art, telehealth equipment to improve the assessment and delivery of care to adolescents and adults with CF.
PUBLIC HEALTH RELEVANCE: The primary goal of this proposal is to perform a clinical trial to determine the efficacy of early intervention in the treatment of adolescent and adult CF acute pulmonary exacerbation using remote monitoring with home spirometry and respiratory symptom assessment and protocolized management of CF exacerbation. This approach will utilize state of the art, telehealth equipment to improve the assessment and delivery of care to adolescents and adults with CF.
描述(申请人提供):囊性纤维化(CF)患者每天都会出现咳嗽和呼吸困难等呼吸道症状。尽管护理有了显著的改善,但由于渐进性呼吸衰竭,他们的寿命大大缩短。CF的病程以反复的肺加重为特征,以症状恶化和肺功能下降为特征。Cf急性肺加重导致肺功能更迅速地下降和增加。我们小组的初步数据表明,在病情恶化后,延迟寻求治疗与肺功能缺乏恢复有关。这项建议的主要目标是进行一项临床试验,以确定早期干预在青少年和成人CF急性肺加重治疗中的效果。这项研究将评估两种治疗慢性阻塞性肺疾病肺加重的新方法的整合:1)使用家庭肺活量计来识别和触发肺恶化的治疗;以及2)使用基于家庭的患者症状评估来识别和触发肺加重的治疗,两者都被整合到一个协议化的护理计划中。这一新方法将与常规护理进行比较,主要结果是用第一秒用力呼气量(FEV1)测量肺功能。我们推测,如果及早采用多方面的干预措施治疗肺恶化,肺部疾病的进展将会放缓。这一方法将利用最先进的远程医疗设备来改进对患有CF的青少年和成年人的评估和提供护理。
公共卫生相关性:这项建议的主要目标是进行一项临床试验,以确定早期干预在青少年和成人CF急性肺加重治疗中的有效性,方法是使用远程监测、家庭肺活量测定和呼吸系统症状评估,以及对CF加重的程序化处理。这一方法将利用最先进的远程医疗设备来改进对患有CF的青少年和成年人的评估和提供护理。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Christopher Hooper Goss其他文献
Christopher Hooper Goss的其他文献
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{{ truncateString('Christopher Hooper Goss', 18)}}的其他基金
A Phase 1b, Multi-center Study of IV Gallium Nitrate in Patients with Cystic Fibrosis who are colonized with Nontuberculosis Mycobacterium (The ABATE Study).
一项针对非结核分枝杆菌定植的囊性纤维化患者静脉注射硝酸镓的 1b 期多中心研究(ABATE 研究)。
- 批准号:
10237132 - 财政年份:2020
- 资助金额:
$ 80.97万 - 项目类别:
Proof of Principle Evaluation of IV Gallium Nitrate in Patients with CF
IV 硝酸镓治疗 CF 患者的原理评估证明
- 批准号:
8544677 - 财政年份:2013
- 资助金额:
$ 80.97万 - 项目类别:
Early Intervention in Pulmonary Exacerbation in CF
CF 肺部病情加重的早期干预
- 批准号:
8690951 - 财政年份:2010
- 资助金额:
$ 80.97万 - 项目类别:
Early Intervention in Pulmonary Exacerbation in CF
CF 肺部病情加重的早期干预
- 批准号:
8149884 - 财政年份:2010
- 资助金额:
$ 80.97万 - 项目类别:
Early Intervention in Pulmonary Exacerbation in CF
CF 肺部病情加重的早期干预
- 批准号:
8534241 - 财政年份:2010
- 资助金额:
$ 80.97万 - 项目类别:
Early Intervention in Pulmonary Exacerbation in CF
CF 肺部病情加重的早期干预
- 批准号:
8323926 - 财政年份:2010
- 资助金额:
$ 80.97万 - 项目类别:
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