Telephone IPT Intervention for HIV-Infected Rural Persons

农村艾滋病病毒感染者电话IPT干预

• 批准号: 7853753
• 负责人: Timothy Glenn Heckman
• 金额: $ 38.84万
• 依托单位: OHIO UNIVERSITY ATHENS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7853753
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adherence; Agriculture; Antidepressive Agents; Area; Cessation of life; Client; Clinical Trials; Code; Communication; Communities; Conflict (Psychology); County; Data; Data Collection; Diagnosis; Disease; Disputes; Divorce; Drug abuse; Dysthymic Disorder; Eligibility Determination; Enrollment; Epidemic; Feeling suicidal; Goals; Grief reaction; HIV; Health Professional; Individual; Intervention; Interview; Life; Linear Models; Loneliness; Major Depressive Disorder; Mental Depression; Mental Health; Mental disorders; Methodology; Modeling; Nature; Occupations; Outcome Measure; Partial Remission; Participant; Pattern; Perception; Persons; Pharmaceutical Preparations; Psychiatric Social Work; Psychotherapy; Public Health; Randomized; Randomized Clinical Trials; Recruitment Activity; Reporting; Research; Role; Rural; Screening procedure; Self-Administered; Series; Services; Social support; Support Groups; Surveys; System; Technology; Telemedicine; Telephone; Telephone Interviews; Testing; Therapeutic; Time; United States; Visit; Voice; active method; base; clinically significant; comparison group; depressive symptoms; eligible participant; expectation; experience; follow-up; health care service organization; improved; loved ones; meetings; post intervention; primary outcome; programs; public health relevance; response; rural area; secondary outcome; treatment as usual

DESCRIPTION (provided by applicant): Compared to their urban counterparts, HIV-rural persons are more likely to be diagnosed with depression, less likely to seek assistance from mental health professionals, and appear to have shorter periods of survival. This application responds to PA-07-103 ("Research on Rural Mental Health and Drug Abuse Disorders") and the PA's stated need for research that will "Study whether individuals with various mental disorders can be treated effectively via telemedicine." A pilot RCT recently completed by our team showed that a 6-session telephone-delivered, interpersonal psychotherapy (IPT) intervention reduced depressive symptoms in 79 HIV- infected rural persons (Ransom, Heckman, et al., 2008, Psychiatric Services). This follow-up RCT will enroll 180 persons living with HIV/AIDS in rural counties in the United States who are diagnosed with depression via telephone interviews. Participants will complete self-administered surveys at pre-intervention, post- intervention, and 4- and 8-month follow-up that assess depressive symptoms (the primary outcome measure), interpersonal problems, social support, and ART adherence. Participants will also provide weekly data (for 41 weeks) via interactive voice response (IVR) systems that assess depressive symptoms (41 weeks) and therapeutic alliance (9 weeks). Ninety (n=90) participants will be randomly assigned to a 9-session, one-on- one, telephone-delivered, IPT intervention and 90 will be assigned to a usual care comparison group. Linear mixed models (LMM) will test if IPT participants report greater reductions in depressive symptoms compared to usual care controls. Analyses of reliable change will test if a greater proportion of IPT participants report clinically-significant reductions in depressive symptoms compared to usual care controls. Using weekly data collected via IVR systems, time series analyses will test if IPT participants report greater decreases in depressive symptoms over a 41-week follow-up period compared to usual care control. Mixed models analyses will assess the importance of therapeutic alliance in telephone-delivered IPT. Public Health Significance: This study will test if nine sessions of telephone-administered interpersonal psychotherapy can reduce depressive symptoms in HIV-infected rural persons, a group that is increasing in size and that experiences great difficulty accessing mental health support services. PUBLIC HEALTH RELEVANCE: HIV-infected rural persons are 1.3 times more likely than their urban counterparts to be diagnosed with depression. This randomized clinical trial will test if a nine-session, telephone-administered, interpersonal psychotherapy intervention can reduce depressive symptoms in HIV-infected persons living in rural counties of the United States who are diagnosed with depression.

描述（由申请人提供）：与城市同行相比，艾滋病毒感染者更有可能被诊断患有抑郁症，不太可能寻求心理健康专业人员的帮助，并且似乎生存期较短。这项申请是对PA-07-103（“农村精神健康和药物滥用障碍研究”）和PA所述的研究需要的回应，该研究将“研究患有各种精神障碍的个人是否可以通过远程医疗得到有效治疗。“我们的团队最近完成的一项试点RCT显示，6次电话传递的人际心理治疗（IPT）干预减少了79名艾滋病毒感染者的抑郁症状（Ransom，Heckman等人，2008年，精神病学服务）。这项后续RCT将招募180名美国农村县的艾滋病毒/艾滋病感染者，他们通过电话采访被诊断为抑郁症。参与者将在干预前、干预后以及4个月和8个月随访时完成自我管理调查，评估抑郁症状（主要结局指标）、人际关系问题、社会支持和ART依从性。参与者还将通过交互式语音应答（IVR）系统提供每周数据（41周），评估抑郁症状（41周）和治疗联盟（9周）。90名（n=90）参与者将被随机分配到9个疗程、一对一、电话传递、IPT干预，90名参与者将被分配到常规护理比较组。线性混合模型（LMM）将测试IPT参与者是否报告与常规护理对照相比抑郁症状的减少更大。可靠的变化分析将测试是否有更大比例的IPT参与者报告与常规护理对照相比抑郁症状的临床显着减少。使用通过IVR系统收集的每周数据，时间序列分析将测试IPT参与者在41周的随访期内与常规护理对照组相比，抑郁症状的减少是否更大。混合模型分析将评估治疗联盟的重要性，在电话提供的IPT。公共卫生意义：这项研究将测试9次电话管理的人际心理治疗是否可以减少农村艾滋病毒感染者的抑郁症状，这一群体的规模正在增加，并且很难获得心理健康支持服务。 公共卫生相关性：农村艾滋病毒感染者被诊断为抑郁症的可能性是城市感染者的1.3倍。这项随机临床试验将测试九次电话管理的人际心理治疗干预是否可以减少生活在美国农村县被诊断患有抑郁症的艾滋病毒感染者的抑郁症状。