A Parylene Ribbon Cable for Neural Prosthetic Applications

用于神经修复应用的聚对二甲苯带状电缆

• 批准号: 7997263
• 负责人: Sandeep Negi
• 金额: $ 10.11万
• 依托单位: BLACKROCK MICROSYSTEMS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-23 至 2012-03-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7997263
• 关键词: Address; Anesthesia procedures; Biocompatible; Bionics; Caliber; Chronic; Development; Devices; Electrodes; Electronics; Encapsulated; Evaluation; Face; Family; Film; Future; Gold; Implant; In Vitro; Inflammation; Lead; Link; Mechanics; Metals; Methodology; Methods; Metric; Motion; Neurosciences; Operative Surgical Procedures; Patients; Performance; Phase; Plasma; Polymers; Positioning Attribute; Process; Property; Prosthesis; Qualifying; Relative (related person); Research; Research Personnel; Residual state; Resistance; Science; Shunt Device; Silicone Elastomers; Stress; Structure; Surgeon; System; Techniques; Technology; Teflon; Temperature; Testing; Time; Tissue Microarray; Tissues; Utah; Validation; Work; base; biocompatible polymer; biomaterial compatibility; cost; cost effective; design; electrical property; experience; flexibility; implantation; in vitro testing; in vivo; innovation; loss of function; meetings; microsystems; neural prosthesis; neurotechnology; parylene; parylene C; phase 2 study; polymerization; public health relevance; relating to nervous system; success; vapor

DESCRIPTION (provided by applicant): This project addresses the process development and evaluation of an extremely flexible, Parylene C, micro-ribbon cable that is both biocompatible and biostable. Such a cable would be employed to link micro-electrode arrays with percutaneous connectors as well as with other in vivo micro-electronic arrays and modules. The key innovation is the approach utilized to form a monolithic structure with the array and connector directly incorporated into the ribbon cable. Thus there is no need to connect the cable to the array and connector after its synthesis. The primary advantages are extreme flexibility and low modulus resulting in easy placement of the electrode array and minimal to no residual tethering forces exerted on the array in vivo. A third advantage is the wide range of cable designs that can be easily and inexpensively fabricated using MEMs photolithographic processes. After process development validations will focus on designs for enhanced flexibility and stress relief as well as in vitro testing of electrical and mechanical properties. The key criteria for success are to develop a method of manufacturing a monolithic ribbon cable structure followed by evaluation, of the cable in terms of acceptable flexibility (as determined by key neuroscience researchers), mechanical and electrical stability in accelerated in vitro testing and finally feasibility and ease of manufacture at an acceptable cost.

描述（由申请人提供）：本项目涉及一种具有生物相容性和生物稳定性的极柔性聚对二甲苯C微带电缆的过程开发和评价。这种电缆将用于将微电极阵列与经皮连接器以及与其他体内微电子阵列和模块连接。关键的创新是用于形成整体结构的方法，其中阵列和连接器直接并入带状电缆中。因此，在其合成之后不需要将电缆连接到阵列和连接器。主要优点是极高的柔性和低模量，从而易于放置电极阵列，并且在体内对阵列施加的残余束缚力最小甚至没有。第三个优点是广泛的电缆设计，可以很容易地和廉价地制造使用MEMS MEMS MEMS工艺。工艺开发后，确认将侧重于增强柔性和应力消除的设计以及电气和机械性能的体外测试。成功的关键标准是开发一种制造单片带状电缆结构的方法，然后根据可接受的柔性（由关键神经科学研究人员确定）、加速体外测试中的机械和电气稳定性以及最终以可接受的成本制造的可行性和易用性对电缆进行评估。