Water-Equivalent Plastic Scintillation Detectors for Small-Field Radiotherapy

用于小场放射治疗的水当量塑料闪烁探测器

• 批准号: 8005430
• 负责人: Daniel G. Schmidt
• 金额: $ 22.58万
• 依托单位: STANDARD IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-10 至 2011-08-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8005430
• 关键词: Algorithms; Autacoids; Behavior; Boxing; Caliber; Calibration; Cancer Center; Characteristics; Clinic; Clinical; Color; Computer software; Coupled; Coupling; Development; Devices; Dose; Elements; Ensure; Evaluation; Fiber; Fiber Optics; Figs - dietary; Floor; Funding; Generations; Germany; Goals; Government; Human body; Image; Individual; Intensity-Modulated Radiotherapy; International; Laboratories; Light; Measurement; Measures; Medical; Medical Device; Methods; Microprocessor; Modeling; Noise; Optics; Output; Patient Care; Patients; Performance; Persons; Phase; Plastics; Polishes; Polystyrenes; Positioning Attribute; Procedures; Property; Radiation; Radiation therapy; Radiometry; Radiosurgery; Reading; Reporting; Resistance; Running; Safety; Services; Signal Transduction; Site; Software Design; System; Technology; Temperature; Testing; Time; Tissues; Water; Work; base; charge coupled device camera; clinical application; clinical practice; density; design; detector; dosimetry; improved; instrument; irradiation; lens; meetings; miniaturize; optical fiber; phase 1 study; phase 2 study; prototype; public health relevance; response

DESCRIPTION (provided by applicant): Standard Imaging, Inc. is developing a new generation of radiation dosimeters for small field dosimetry, which are needed in clinical applications such as stereotactic radiosurgery/ stereotactic radiotherapy (SRS/SRT), intensity modulated radiation therapy (IMRT), dynamical arc therapy and tomotherapy treatments. The enabling technology is the point scintillation detector which employs a miniature plastic scintillator coupled to a color PIN diode detector via an optical fiber. The overall aim of this project is to transform the critical performance features of a proven benchtop Plastic Scintillation Detector (PSD) system into a reliable, miniaturized PSD system that eliminates cumbersome optical subsystems and is suitable for daily usage in typical clinical settings. This project will design, build, and test a Plastic Scintillator Detector and will result in a prototype system that can be characterized for use in small fields. To bring the scintillation detector system from the benchtop to the clinic, several strategies will be implemented. First, the CCD-based photodetector will be replaced with a PIN diode. This will permit subtraction of Cerenkov noise without the need to separate the light signal with filters. Second, the optics will be replaced with a simple direct coupling to the PIN diode. This will enable replacing the bulky optical bench with a small black box that can easily be placed on the treatment couch. Finally, modified software designed to run on the Standard Imaging SuperMAX electrometer with specific features for this application will be developed during this Phase I study. Two complete prototype systems will be independently tested-one at a collaborative medical site under realistic clinical conditions by experts in the field and one at Standard Imaging's facilities; instrument behavior will be fully characterized. Standard Imaging has obtained the services of two individuals who are internationally renowned experts in scintillation dosimetry and have been pioneering the development of scintillation dosimetry for radiotherapy applications for more than a decade. In Phase II, this new miniature radiation PSD system will be commercialized for use in the clinic. PUBLIC HEALTH RELEVANCE: Patients undergoing very delicate radiation treatment, such as stereotactic radiosurgery/ stereotactic radiotherapy (SRS/SRT), intensity modulated radiation therapy (IMRT), dynamical arc therapy, or tomotherapy treatments, need extremely precise and accurate doses. Current methods are adequate, but could be much better. Standard Imaging is developing a reliable, miniaturized Plastic Scintillation Detector (PSD) system that will accurately measure the actual radiotherapy dose-and improve patient care and safety.

描述（由申请人提供）：Standard Imaging, Inc.正在开发用于小场剂量测定的新一代放射剂量计，用于立体定向放射外科/立体定向放射治疗（SRS/SRT），调强放射治疗（IMRT），动态电弧治疗和断层治疗等临床应用。使能技术是点闪烁探测器，它采用微型塑料闪烁体通过光纤与彩色PIN二极管探测器耦合。该项目的总体目标是将经过验证的台式塑料闪烁检测器（PSD）系统的关键性能特征转变为可靠的小型化PSD系统，该系统消除了繁琐的光学子系统，适合典型临床环境的日常使用。该项目将设计、建造和测试一个塑料闪烁体探测器，并将产生一个原型系统，可以用于小型领域。为了将闪烁探测器系统从台式带到临床，将实施几个策略。首先，基于ccd的光电探测器将被PIN二极管取代。这将允许切伦科夫噪声的减法，而不需要用滤波器分离光信号。其次，光学器件将被替换为一个简单的直接耦合到PIN二极管。这将使得用一个小的黑色盒子取代笨重的光学工作台，可以很容易地放在治疗台上。最后，在第一阶段的研究中，将开发用于标准成像SuperMAX静电计的修改软件，该软件具有该应用程序的特定功能。两个完整的原型系统将被独立测试——一个在实际临床条件下由该领域的专家在合作医疗站点进行测试，另一个在标准成像公司的设施进行测试；仪器行为将被充分表征。Standard Imaging获得了两名国际知名闪烁剂量学专家的服务，十多年来一直引领闪烁剂量学在放疗应用中的发展。在第二阶段，这种新的微型辐射PSD系统将商业化用于临床。