Noninvasive Dental Implant Imaging System

无创牙种植体成像系统

• 批准号: 8001911
• 负责人: Rahul Singh
• 金额: $ 10万
• 依托单位: FARUS, LLC
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-16 至 2011-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8001911
• 关键词: Anatomy; Biological Preservation; Blood Vessels; Clinic; Clinical; Complication; Data; Defect; Dental Implants; Dentistry; Dentists; Detection; Diagnostic radiologic examination; Electronics; Ensure; Esthetics; Family suidae; Feedback; Gingiva; Hand; Healed; Image; Imagery; Implant; Implantation procedure; In Situ; In Vitro; Ionizing radiation; Jaw; Knowledge; Labyrinth fenestration; Location; Measurement; Measures; Mechanics; Modeling; Morbidity - disease rate; Mucous Membrane; Nerve; Operative Surgical Procedures; Outcome; Patients; Penetration; Phase; Price; Procedures; Prosthesis; Prosthodontic specialty; Prosthodontist; Psyche structure; ROC Curve; Research; Scanning; Site; Small Business Innovation Research Grant; Specialist; Surface; Surgical Flaps; System; Techniques; Technology; Testing; Thick; Time; Tissue Grafts; Tissues; Transducers; Trauma; Ultrasonic Transducer; Ultrasonography; United States; Work; base; cost; design; ergonomics; hazard; healing; improved; instrument; interest; minimally invasive; public health relevance; research study; restoration; soft tissue; statistics; treatment planning

DESCRIPTION (provided by applicant): Dental implants are the fastest growing field in dentistry. However, high complication rates result in significant morbidity, cost, and disappointment. Better pre-operative knowledge of soft tissue thickness and hard tissue contour could dramatically cut complication rates. Current soft tissue thickness measurement techniques for implant procedures involve somewhat inaccurate mechanical penetration of the delicate soft tissues with sharp probes or radiography which is not optimal for soft tissue measurements. A noninvasive ultrasound imaging system is proposed that can potentially improve implant procedures by enabling: (1) accurate non-invasive preoperative measurement of soft tissue thickness, including soft tissue grafts; (2) identification of important surface bony features such as foramina; (3) identification of bony defects or fenestrations; and (4) precise location of buried healing implants with precise measurement of overlying tissue thickness. Ultrasound is ideally suited for this application, because: (a) it can be used in real-time before or during surgeries; (b) data is directly located to the exact site being imaged on the patient, as directly viewed by the dentist; (c) it is non- invasive and without ionizing radiation; and (d) it can be performed with an inexpensive and portable instrument. If successful, the system is expected to lower the overall societal cost of implant therapy by decreasing the need for expensive adjunctive procedures necessitated by surgical, prosthodontic and esthetic complications; 150,000 such adjunctive procedures were required in 2005-06. Additionally, the system will improve the quality and predictability of routine implant outcomes (especially facilitating the use minimally invasive flapless surgery) - important to both dentists and patients. The objective of this Phase I SBIR effort is to demonstrate the technical feasibility of a noninvasive ultrasound imaging system for dental implant procedures. The ultrasound system will ultimately be designed to feature a B-scan transducer that provides high quality 2D imagery, packaged in an ergonomic hand piece, with customized system electronics and simple display, all in a portable, low cost system. Technical feasibility of the approach will be achieved in this Phase I SBIR effort by (1) designing a B-scan ultrasound setup, based from prior work; (2) performing in-vitro studies using porcine jaws, and (3) analyzing measurement and detection statistics using ROC curves. PUBLIC HEALTH RELEVANCE: Dental implants are the fastest growing field in dentistry, but there is currently a high complication rate resulting in the need for a great many adjunctive procedures and less than optimal functional and esthetic outcomes. A noninvasive ultrasound imaging system has the potential to improve site assessment, treatment planning, surgical procedure, and uncovery by enabling accurate identification and measurement of soft tissue thicknesses, bony defects and dehiscences, mental and other foramina, jawbone thickness, and the precise location of buried healing implants. If successful, the system is expected to lower the overall societal cost of implant therapy, facilitate minimally invasive flapless surgery, and improve the quality and predictability of routine implant outcomes - important to both dentists and patients.

描述（由申请人提供）：牙科植入物是牙科中增长最快的领域。然而，高并发症发生率导致显著的发病率、成本和失望。术前更好地了解软组织厚度和硬组织轮廓可以显著降低并发症发生率。当前用于植入手术的软组织厚度测量技术涉及用尖锐探针或射线照相术对精细软组织的稍微不准确的机械穿透，这对于软组织测量不是最佳的。提出了一种非侵入性超声成像系统，其可以通过以下方式潜在地改进植入过程：（1）对包括软组织移植物在内的软组织厚度进行精确的非侵入性术前测量;（2）识别重要的表面骨特征，例如孔;（3）识别骨缺损或开窗;以及（4）通过精确测量覆盖组织厚度来精确定位埋入的愈合植入物。超声波理想地适合于这种应用，因为：（a）它可以在手术之前或手术期间实时使用;（B）数据直接定位到患者上被成像的确切部位，如牙医直接观察的那样;（c）它是非侵入性的并且没有电离辐射;以及（d）它可以用便宜且便携的仪器来执行。如果成功的话，该系统有望通过减少因手术、口腔修复和美容并发症而需要的昂贵的修复手术来降低种植治疗的总体社会成本; 2005- 2006年需要150，000例这样的修复手术。此外，该系统将提高常规种植体结果的质量和可预测性（特别是促进微创无翻瓣手术的使用）-这对牙医和患者都很重要。第一阶段SBIR工作的目的是证明牙科种植手术中无创超声成像系统的技术可行性。超声系统最终将设计为具有B扫描换能器，该换能器提供高质量的2D图像，包装在符合人体工程学的手持件中，具有定制的系统电子设备和简单的显示器，所有这些都在便携式低成本系统中。该方法的技术可行性将在第I阶段SBIR工作中通过以下方式实现：（1）基于先前工作设计B扫描超声设置;（2）使用猪颌骨进行体外研究;（3）使用ROC曲线分析测量和检测统计数据。 公共卫生相关性：牙科种植体是牙科中发展最快的领域，但目前存在高并发症率，导致需要大量的预防性手术，并且功能和美学效果不佳。非侵入性超声成像系统有可能通过精确识别和测量软组织厚度、骨缺损和开裂、颏孔和其他孔、颌骨厚度以及埋藏愈合植入物的精确位置来改善部位评估、治疗计划、外科手术和非精细化。如果成功，该系统有望降低种植体治疗的整体社会成本，促进微创无翻瓣手术，并提高常规种植体结果的质量和可预测性-这对牙医和患者都很重要。