Connective Tissue Motion Measure

结缔组织运动测量

• 批准号: 7918324
• 负责人: Robert T Davis
• 金额: $ 24.33万
• 依托单位: STROMATEC, INC
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7918324
• 关键词: Acupuncture procedure; Aftercare; Back; Back Pain; Basic Science; Behavior; Biological Markers; Biomechanics; Chronic; Chronic low back pain; Clinical; Clinical Management; Clinical Research; Computers; Connective Tissue; Data; Data Analyses; Devices; Diagnosis; Diagnostic; Goals; Human; In Vitro; Intervention; Link; Low Back Pain; Manipulative Therapies; Manuals; Massage; Measurement; Measures; Methods; Monitor; Motion; Musculoskeletal Diseases; Musculoskeletal Pain; Needles; Outcome Measure; Patients; Phase; Physiological; Pilot Projects; Procedures; Research; Research Personnel; Sample Size; Stimulus; System; Techniques; Technology; Testing; Therapeutic Effect; Tissues; Translating; Ultrasonic Transducer; Universities; Validation; Vermont; Work; Yoga; chronic pain; design; functional status; human subject; in vivo; innovation; insight; interest; public health relevance; tool; user-friendly; validation studies

DESCRIPTION (provided by applicant): The goal of this project is to develop a biomarker - the Connective Tissue Motion Measure (CTMM) - quantifying the functional behavior of perimuscular connective tissues. The differential motion between specific connective tissue strata will be measured during tissue displacement (linear oscillation) initiated by a computer-controlled needle stimulus tool (NST). The CTMM will be suitable as an outcome measure for mechanistic and clinical studies of CAM interventions. The CTMM also will potentially serve as a clinical diagnostic and treatment-monitoring tool for manual therapists, acupuncturists, and CAM clinicians interested in assessing the functional status of a patient's connective tissue. Our Specific Aims are: Aim 1: Develop an integrated, user-friendly, and reliable system for conducting the CTMM. 1) Design and fabricate an automated Needle Stimulus Tool (NST) capable of providing a controlled displacement stimulus to the targeted connective tissue strata. 2) Integrating the NST with an ultrasound transducer in a clinically practical configuration allowing for the measurement and analysis of tissue displacement. 3) Preliminary validation of optimal CTMM procedures and data analysis techniques by performing the measure 1) in-vitro and 2) in-vivo in 5 human subjects. Milestones: Successful completion of Aim I of this work will be indicated by the following: 1. Completion of an operational NST device which is capable of achieving the target linear needle motion requirements. 2. Successful testing of the overall CTMM system demonstrating that the target needling accuracy requirements are achieved in-vitro, and in-vivo. Aim 2: Perform a pilot study of CTMM in human subjects with chronic low back pain (cLBP). Using optimal procedures determined in Aim 1c, we will test 17 subjects with chronic low back pain (cLBP) and 17 control subjects without cLBP. Milestone: Successful completion of Aim I of this work will be indicated by the following: Acquisition of preliminary data allowing sample size calculations for full-scale validation studies of the CTMM which will be conducted during Phase 2. PUBLIC HEALTH RELEVANCE: This project attempts to provide researchers and clinicians with a biomarker - the Connective Tissue Motion Measure - capable of documenting and monitoring the functional status of human connective tissues. Its purpose is to function as an outcome measure to monitor the effect of therapies that may have a therapeutic effect on connective tissue including manual therapies and yoga as well as acupuncture. It is anticipated that this technology will establish the usefulness of connective tissue motion measurements for the diagnosis and clinical management of chronic musculoskeletal pain in general, including low back pain.

描述（由申请人提供）：该项目的目标是开发一种生物标志物-结缔组织运动测量(CTMM) -量化肌肉周围结缔组织的功能行为。在由计算机控制的针刺激工具（NST）启动的组织位移（线性振荡）期间，将测量特定结缔组织层之间的差动。CTMM将适合作为CAM干预的机制和临床研究的结果测量。CTMM也有可能作为一种临床诊断和治疗监测工具，供对评估患者结缔组织功能状态感兴趣的手工治疗师、针灸师和CAM临床医生使用。我们的具体目标是：目标1：开发一个集成的、用户友好的、可靠的系统来进行CTMM。1)设计和制造一种能够向目标结缔组织层提供可控位移刺激的自动针刺刺激工具（NST）。2)将NST与超声换能器集成在临床实用配置中，允许测量和分析组织位移。3)通过对5名人类受试者进行1)体外和2)体内测量，初步验证最佳CTMM程序和数据分析技术。里程碑：成功完成本工作的目标1将通过以下方式表示：完成一个可操作的NST装置，该装置能够达到目标直线针运动要求。2. 整个CTMM系统的成功测试表明，在体外和体内都达到了目标针刺精度要求。目的2：对慢性腰痛（cLBP）患者进行CTMM的试点研究。使用Aim 1c中确定的最佳程序，我们将测试17名慢性腰痛（cLBP）患者和17名无cLBP的对照组。里程碑：成功完成本工作的目标I将通过以下方式表示：获得初步数据，允许在第二阶段进行CTMM全面验证研究的样本大小计算。