High Throughput, Label-Fee Molecular Interaction Platform for Membrane Protein Ta

高通量、免标记的膜蛋白 Ta 分子相互作用平台

• 批准号: 7926683
• 负责人: Scot Randy Weinberger
• 金额: $ 20万
• 依托单位: MOLECULAR SENSING, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-26 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7926683
• 关键词: Address; Applications Grants; Back; Binding; Biological Assay; Biological Models; Biological Sciences; Biology; Bradykinin B1 Receptor; Businesses; Cell Membrane Proteins; Cell membrane; Cells; Chemicals; Chemistry; Clinical; Complex; Computer software; Data; Detection; Development; Diagnostic; Disease; Drug Delivery Systems; Environment; Failure; Fees; Foundations; Future; G-Protein-Coupled Receptors; Healthcare; Hour; Human; Immobilization; Interferometry; Label; Lead; Ligands; Lipids; Manuals; Measurement; Membrane; Membrane Proteins; Metabolism; Modification; Molecular; Monitor; Noise; Optics; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Phospholipids; Physiological; Polymers; Preparation; Proteome; Protocols documentation; Reading; Reproducibility; Research; Research Support; Robotics; Sampling; Serum; Small Business Innovation Research Grant; Solutions; Staging; Surface; System; Techniques; Technology; Testing; Therapeutic; Time; Work; base; catalyst; cost; design; drug discovery; high throughput screening; improved; instrument; interest; monolayer; novel; operation; programs; prototype; public health relevance; software systems; surface coating; tool

DESCRIPTION (provided by applicant): Our program will create a novel high throughput (HT) screening tool to address unmet needs in the research of valuable drug targets that are located within cell membranes. We intend to create novel surface chemistries, sample preparation protocols, system software, and robotics that will be combined with our proprietary molecular interaction detection technology known as Back-scattering Interferometry. We will demonstrate the value of this platform by analyzing a commercially available cell membrane protein system and its natural interacting molecule. Once completed, our new HT screening platform is envisioned to contribute to the development of valuable therapeutics and diagnostics, making a significantly positive impact upon healthcare. PUBLIC HEALTH RELEVANCE: Drugs directed against cell membrane targets comprise one of the most important classes of therapeutics and focused pharmaceutical research. Tools available to support this research lack enabling capabilities, and are a barrier to progress. Our program will result in the creation of a novel research platform that will exert a substantial and powerful impact to advance progress in membrane target drug research, yielding new and improved therapeutics that will positively impact the treatment of disease, improving healthcare while reducing its cost.

描述（由申请人提供）：我们的计划将创建一个新的高通量（HT）筛选工具，以解决未满足的需求，在研究有价值的药物靶点，位于细胞膜内。我们打算创建新的表面化学，样品制备方案，系统软件和机器人技术，这些技术将与我们专有的分子相互作用检测技术（称为反向散射干涉法）相结合。我们将通过分析商业上可获得的细胞膜蛋白系统及其天然相互作用分子来证明该平台的价值。一旦完成，我们的新HT筛查平台将有助于开发有价值的治疗和诊断方法，对医疗保健产生显著的积极影响。 公共卫生相关性：针对细胞膜靶点的药物是最重要的一类治疗药物和重点药物研究。可用于支持这项研究的工具缺乏使能能力，是取得进展的障碍。我们的计划将导致创建一个新的研究平台，这将对推进膜靶向药物研究的进展产生重大而强大的影响，产生新的和改进的治疗方法，这将对疾病的治疗产生积极影响，改善医疗保健，同时降低其成本。