Microspect Scanner for Small Animal Radionuclide Imaging

描述（由申请人提供）：申请资金用于购买双探测器microSPECT扫描仪（NanoSPECT/CT扫描仪，BioScan，Inc.）致力于小动物研究。放射性核素成像是研究生命系统中分子事件的有力工具。威斯康星州医学院（MCW）或威斯康星州没有这种高分辨率SPECT扫描仪。该仪器将成为MCW现有多模态成像核心设施的一个组成部分，并通过提供非侵入性、三维、定量和纵向测量，使广泛的研究项目受益。拟议的扫描仪将发挥重要作用的基础和转化研究，使用新的和建立的临床成像剂和技术。来自高度跨学科研究网络的八个NIH资助的项目（PPG）和20名NIH资助的研究人员将形成五个主要用户组，包括癌症，心血管，肺，再生医学和肾脏研究。该工具还将供区域研究界的少数用户使用。最先进的小动物SPECT/CT扫描仪将立即大大提高当地研究活动的生产力。 与公共卫生的关系：要求提供资金，以便能够购买一台专用于小动物成像研究的双探测器微型SPECT扫描仪。拟议的扫描仪将在基础和转化研究中发挥重要作用，支持五个主要用户组（8个NIH资助的PPG和20名研究人员），包括癌症、心血管、肺、再生医学和肾脏研究。该工具还将供区域研究界的少数用户使用。一个国家的最先进的小动物SPECT扫描仪将立即和显着提高当地的研究活动的生产力从一个高度跨学科的网络。

DESCRIPTION (provided by applicant): Funds are requested for the purchase of a dual-detector microSPECT scanner (NanoSPECT/CT scanner, BioScan, Inc.) dedicated to small animal research. Radionuclide imaging constitutes a robust tool for the investigation of molecular events in the living system. A high- resolution SPECT scanner of this kind is not available at the Medical College of Wisconsin (MCW), or in the state of Wisconsin. The instrument will become an integral part of the existing multi- modality imaging core facility at MCW and benefit a broad range of research projects by providing noninvasive, three-dimensional, quantitative and longitudinal measurements. The proposed scanner will play a major role in the basic and translational research using novel and established clinical imaging agents and techniques. Eight NIH-funded Program Projects (PPGs) and 20 NIH-funded investigators from a highly interdisciplinary research network will form five major user groups, encompassing cancer, cardiovascular, pulmonary, regenerative medicine, and renal studies. The instrument will also be shared by minor users in the regional research community. A state-of-the-art small animal SPECT/CT scanner will immediately and significantly advance the productivity of local research activities. PUBLIC HEALTH RELEVANCE: Funds are requested to enable the purchase of a dual-detector microSPECT scanner dedicated to small animal imaging research. The proposed scanner will play a major role in the basic and translational research, supporting five major user groups (8 NIH-funded PPGs and 20 investigators) encompassing cancer, cardiovascular, pulmonary, regenerative medicine, and renal studies. The instrument will also be shared by minor users in the regional research community. A state-of-the-art small animal SPECT scanner will immediately and significantly advance the productivity of local research activities from a highly interdisciplinary network.