Lantibiotics as probes for phosphatidylethanolamine.
Lantibiotics as probes for phosphatidylethanolamine.
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DOI：
10.1007/s00726-009-0386-9
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发表时间：
2011-11
期刊：
影响因子：
3.5
通讯作者：
Zhao, Ming
中科院分区：
文献类型：
--
作者：
Zhao, Ming
磷脂酰乙醇胺（PE）是哺乳动物质膜的主要成分。它主要存在于活的典型哺乳动物细胞中膜双层的内小叶中。然而，越来越多的证据表明，一些生物事件涉及PE外化。例如，PE集中在有丝分裂子细胞之间的卵裂沟表面，并与收缩环的动力学相关。在凋亡细胞中，PE暴露于细胞表面，从而提供用于检测的分子标记。此外，PE是抗凝机制中的辅助因子，并且已记录了PE在血液-内皮界面处的独特分布特征。这些最近的发现是使用衍生自duramycin和cinnamycin的PE特异性探针而实现的，duramycin和cinnamycin是B型羊毛硫抗生素的成员。本文综述了这些PE特异性羊毛硫抗生素的特点，在分子探针的背景下，在细胞和组织水平上的表征PE。根据现有的数据，PE可能是一种多功能的化学物质，在规定的生物和生理活性的调节中发挥作用。基于卵磷脂的分子探针的实用程序将有助于加速表征PE作为一个丰富的，但难以捉摸的膜组件。
Phosphatidylethanolamine (PE) is a major component in the mammalian plasma membrane. It is present mainly in the inner leaflet of the membrane bilayer in a viable, typical mammalian cell. However, accumulating evidence indicates that a number of biological events involve PE externalization. For instance, PE is concentrated at the surface of cleavage furrow between mitotic daughter cells and is correlated with the dynamics of contractile ring. In apoptotic cells, PE is exposed to the cell surface, thus providing a molecular marker for detection. In addition, PE is a cofactor in the anticoagulant mechanism, and a distinct distribution profile of PE has been documented at the blood–endothelium interface. These recent discoveries were made possible using PE-specific probes derived from duramycin and cinnamycin, which are members of type B lantibiotics. This review provides an account on the features of these PE-specific lantibiotics in the context of molecular probes for the characterization of PE on a cellular and tissue level. According to the existing data, PE is likely a versatile chemical species that plays a role in the regulation of defined biological and physiological activities. The utilities of lantibiotic-based molecular probes will help accelerate the characterization of PE as an abundant, yet elusive membrane component.
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影响因子：
4.8
作者：
Kato, U;Emoto, K;Umeda, M
通讯作者：
Umeda, M
DOI：
10.1016/0005-2736(88)90192-7
发表时间：
1988-05-24
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
CHOUNG, SY;KOBAYASHI, T;INOUE, K
通讯作者：
INOUE, K
DOI：
10.1073/pnas.93.23.12867
发表时间：
1996-11-12
影响因子：
11.1
作者：
Emoto, K;Kobayashi, T;Umeda, M
通讯作者：
Umeda, M
影响因子：
3.6
作者：
Brötz, H;Josten, M;Sahl, HG
通讯作者：
Sahl, HG
影响因子：
2.9
作者：
Machaidze, G;Seelig, J
通讯作者：
Seelig, J