权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

600MHz Varian VNMRS Console Upgrade

600MHz 瓦里安 VNMRS 控制台升级

基本信息

批准号：
7792178
负责人：
Michael K Rosen
金额：
$ 25.42万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-20 至 2012-07-19
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The nuclear magnetic resonance (NMR) spectrometer subject of this application supports a wide range of research among numerous investigators at UT Southwestern Medical Center. It allows the study of protein structure, dynamics, and molecular interactions on medically and biologically relevant systems. For example, Dr. Michael Rosen studies cytoskeletal dynamics, an important biological process involved in cell migration, adhesion, establishment and maintenance of polarity, and vesicle trafficking. Dr. Jose Rizo-Rey aims to understand the regulation of neurotransmitter release by proteins involved in membrane fusion. Dr. Kevin Gardner is interested in how signal transduction of environmental cues, like xenobiotics, light, and oxygen are ultimately involved in gene regulation. Dr. Xuelian Luo is characterizing the regulation of the spindle checkpoint signaling during cell mitosis, the chromosome inheritance point of the cell cycle. These systems are important to basic biology and to developing new methods to diagnose and treat human disease. The NMR spectrometer is over 10 years old, and uses technology no longer produced by the instrument manufacturer. Repairs are increasingly frequent and expensive, take longer, and soon will not be possible. This proposal requests funds to purchase a new 600MHz NMR spectrometer console. The console is the heart of a NMR spectrometer since it contains all the digital and radiofrequency electronics necessary to acquire NMR experiments. This equipment will continue supporting NIH-funded programs in the laboratories of Dr. Michael Rosen, Dr. Jose Rizo-Rey, Dr. Kevin Gardner, and Dr. Xuelian Luo, thus facilitating the above stated research. Additionally, this equipment will also be available to the UT Southwestern community in need of NMR data for biophysical studies on an even wider range of important biological processes.

描述（由申请人提供）：本申请的核磁共振（NMR）光谱仪主题支持德克萨斯大学西南医学中心众多研究人员的广泛研究。它允许在医学和生物学相关系统上研究蛋白质结构、动力学和分子相互作用。例如，Michael Rosen博士研究细胞骨架动力学，这是一个重要的生物过程，涉及细胞迁移、粘附、极性的建立和维持以及囊泡运输。Jose Rizo-Rey博士旨在了解参与膜融合的蛋白质对神经递质释放的调节。Kevin Gardner博士感兴趣的是环境信号的转导，如异种生物、光和氧最终如何参与基因调控。罗雪莲博士正在描述细胞有丝分裂过程中纺锤体检查点信号的调节，这是细胞周期的染色体遗传点。这些系统对基础生物学和开发诊断和治疗人类疾病的新方法都很重要。核磁共振光谱仪已经有10多年的历史了，使用的技术不再是仪器制造商生产的。维修越来越频繁和昂贵，需要更长的时间，很快就不可能了。该提案要求拨款购买一台新的600MHz核磁共振光谱仪控制台。控制台是核磁共振光谱仪的心脏，因为它包含了获得核磁共振实验所需的所有数字和射频电子设备。该设备将继续支持美国国立卫生研究院资助的Michael Rosen博士、Jose Rizo-Rey博士、Kevin Gardner博士和Xuelian Luo博士的实验室项目，从而促进上述研究。此外，该设备还将提供给需要核磁共振数据的UT西南社区，用于更广泛的重要生物过程的生物物理研究。