Angiogenin in ALS Pathobiology and Therapy

ALS 病理学和治疗中的血管生成素

• 批准号: 8204527
• 负责人: GUO-FU HU
• 金额: $ 36.34万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-15 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8204527
• 关键词: Actins; Adult; Adverse effects; Amyotrophic Lateral Sclerosis; Animal Model; Animals; Blood; Blood Vessels; Body Weight decreased; Candidate Disease Gene; Cells; Cessation of life; Clinical Research; Code; Data; Defect; Degenerative Disorder; Development; Disease Progression; Dose; Drug Kinetics; Endothelial Cells; Functional disorder; Genes; Goals; Human; Hypoxia; Intraperitoneal Injections; Knockout Mice; Maximum Tolerated Dose; Mediating; Messenger RNA; Missense Mutation; Motor; Motor Neurons; Mus; Muscle; Neuraxis; Neurites; Neurons; Onset of illness; Outcome Study; Partner in relationship; Pathogenesis; Pathology; Patients; Phenotype; Physiology; Play; Proteins; Publishing; Regimen; Reporting; Ribonucleases; Role; Spinal Cord; Staging; Stress; Symptoms; Tamoxifen; Therapeutic; Time; Tissues; Toxic effect; Transgenic Mice; Transgenic Organisms; Variant; Work; angiogenin; clinical application; effective therapy; fetal; improved; in vitro activity; intraperitoneal; loss of function; loss of function mutation; motor neuron degeneration; motor neuron function; mutant; neurotoxicity; overexpression; preclinical study; prevent; public health relevance; transgene expression