Novel Nuclear GRK5 Activity in the heart: Good or Bad?

心脏中的新型核GRK5活动：好还是坏？

• 批准号: 8150069
• 负责人: Walter J. Koch
• 金额: $ 36.5万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8150069
• 关键词: ADRBK1 gene; Adrenergic Agents; Adrenergic Receptor; Animal Model; Binding; Biological Models; Cardiac; Cardiac Myocytes; Cardiovascular system; Cell Nucleus; Cell model; Cessation of life; Chronic; DNA; Data; Family; G Protein-Coupled Receptor Genes; G protein coupled receptor kinase; G-Protein-Coupled Receptors; GRK5 gene; Genetic Transcription; Genetically Engineered Mouse; Genomics; Health; Heart; Heart Hypertrophy; Heart failure; Histone Deacetylase; Histones; Hypertrophy; In Vitro; Injury; Knock-in Mouse; Knockout Mice; Lead; Left; Left Ventricular Dysfunction; Molecular Target; Mus; Muscle Cells; Myocardial; Myocardium; Nuclear; Nuclear Export; Pathogenesis; Phenotype; Phosphorylation; Phosphotransferases; Physiological; Play; Process; Reagent; Regulation; Role; Signal Pathway; Signal Transduction; Stress; Testing; Transgenic Mice; Transgenic Organisms; Ventricular; adrenergic; constriction; desensitization; heart function; improved; in utero; in vivo; mouse model; mutant; novel; overexpression; pressure; repaired; response; response to injury; tool; ventricular hypertrophy