Inflammation and T Lymphocyte Immunoregulation

描述(由申请人提供)：由于其跨学科性质、新技术的快速获取和发展以及与人类疾病的直接相关，免疫学是基础生物医学研究培训的极好工具。令人兴奋的新发现和强大的人类疾病应用的巨大潜力继续吸引着许多最好的学生学习免疫学。现在，越来越多的人可以将我们对免疫的知识转化为临床应用中对T细胞和炎症的操纵，许多下一代免疫学家将在翻译研究中找到有价值的职业。我们认为，翻译研究最好的基础是毫不妥协的严谨的传统博士培训，以及扎实的基础科学基础。经过这种方式培训的科学家对过去获得的知识负责，这些知识现在正在转化为临床应用，并将在未来继续发挥这一作用。然而，我们认识到，传统的博士培训可能会留下许多科学家难以克服的知识鸿沟和对临床医学文化的误解。这些问题限制了一些最优秀的博士科学家进入翻译研究。我们的计划结合了几个创新功能，旨在帮助我们的学员弥合这一差距。我们项目中的21位导师领导着一个互动的跨部门研究社区，涵盖从基因组学和蛋白质组学、细胞内信号通路、细胞生物学、微生物学和细胞免疫学到临床研究和试验的全方位生物医学科学，所有这些都以炎症和T淋巴细胞生物学的调控为中心。在我们的项目中，学习疫苗设计、病毒或细菌免疫逃避、肿瘤免疫学、免疫病理学、移植和自身免疫等不同领域的学生和博士后研究员将受益于作为这个互动研究社区的一部分，学习其他领域的研究方法和进展。我们计划的目标是招收有才华和积极进取的学生和博士后研究员，为他们提供生物医学研究最新技术和概念的坚实基础，让他们接触到转化研究的机会，并培养精确度、好奇心、胆识、想象力、沟通和合作，为他们提供指导独立研究计划和培养下一代生物医学科学家所需的工具。

DESCRIPTION (provided by applicant): Because of its interdisciplinary nature, its rapid acquisition and development of new technologies, and its direct relevance to human disease, immunology is an excellent vehicle for training in basic biomedical research. Exciting new findings and the enormous potential for powerful applications to human disease continue to attract many of the best students to immunology. Increasingly, it is now possible to translate our knowledge of immunity into manipulations of T cells and inflammation in clinical applications, and many of the next generation of immunologists will find rewarding careers in translational research. We believe that the best foundation for translational research is uncompromisingly rigorous traditional PhD training, with a solid basic science basis. Scientists trained in this way have been responsible for past gains in knowledge that are now being translated into clinical applications, and will continue to play this role in the future. Nevertheless, we recognize that traditional PhD training can leave both a knowledge gap and a misunderstanding of the culture of clinical medicine that many scientists find difficult to overcome. These problems limit entry of some of the best PhD scientists into translational research. Our program incorporates several innovative features designed to help our trainees bridge this gap. The twenty-one mentors in our program lead an interactive, interdepartmental research community that covers the full range of biomedical science from genomics and proteomics, intracellular signaling pathways, cell biology, microbiology, and cellular immunology to clinical studies and trials, all centered around regulation of inflammation and T lymphocyte biology. In our program, students and postdoctoral fellows studying areas as distinct as vaccine design, immune evasion by viruses or bacteria, tumor immunology, immunopathology, transplantation, and autoimmunity benefit from learning about methods of investigation and advances in the other areas as part of this interactive research community. The goal of our program is to recruit talented and motivated students and postdoctoral fellows, provide them with a firm foundation in the latest techniques and concepts in biomedical research, expose them to translational research opportunities, and foster precision, curiosity, daring, imagination, communication, and cooperation to give them the tools they need to direct independent research programs and train the next generation of biomedical scientists.