新型 2- 和 3- 支链碳环核苷将被合成并评估-猫眼课题宝

新型 2- 和 3- 支链碳环核苷将被合成并评估

批准号：

8145654

负责人：

Vishnumurthy R Hegde

金额：

$10.35万

依托单位：

ORGANIX, INC.

依托单位国家：

美国

项目类别：

财政年份：

2010

资助国家：

美国

项目状态：

已结题

起止时间：

2010-09-23 至 2012-08-31

来源：

https://reporter.nih.gov/project-details/8145654

关键词：

Adenine Adenosine Kinase Antiviral Agents Appearance Binding Binding Sites Biological Biological Assay Bioterrorism Carbohydrates Carbon Cells Collaborations Deamination Development Disease Drug resistance Elements Enzymes Evaluation Exhibits Future Goals Hepatitis B Virus Hepatitis C virus Herpesviridae Homocysteine Homocystine Hydrogen Bonding Hydrolase In Vitro Influenza Influenza A Virus, H1N1 Subtype Lead Literature Malignant Neoplasms Modification Molecular Conformation Molecular Target National Institute of Allergy and Infectious Disease Nature Nucleosides Orthopoxvirus Outcome Pharmaceutical Preparations Phosphorylation Phosphotransferases Positioning Attribute Poxviridae Property Purines Pyrimidine Reporting Research Project Grants Ribose Series Severe Acute Respiratory Syndrome Smallpox Structure Structure-Activity Relationship Testing Uracil Variant Viral Virus Virus Diseases West Nile virus Yellow Fever adenosine deaminase analog aristeromycin base candidate identification clinically relevant cytosine analog cytotoxicity design erythrose flexibility hydroxyl group inhibitor/antagonist molecular recognition novel nucleoside analog public health relevance purine resistant strain respiratory virus sugar

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DESCRIPTION (provided by applicant): The emergence of new viral diseases such as HCV, SARS, West Nile virus, H1N1 influenza, increased threat of bioterrorism using smallpox and appearance of new viral strains resistant to existing drugs warrants development of new medications. The goal of this proposal is to discover new antiviral candidates to treat such diseases by modifying a lead carbocyclic nucleoside analog. New analogs synthesized will be tested for antiviral activity against a wide array of viruses. PUBLIC HEALTH RELEVANCE: The goal of this proposal is to discover new antiviral candidates to treat new viral diseases such as HCV, SARS, West Nile virus, H1N1 influenza, and bioterrorism agent smallpox. The proposed research project also focuses on the development of new medications to viral strains resistant to existing drugs by modifying a lead carbocyclic nucleoside analog.

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Novel 2'- and 3'- Branched Carbocyclic Nucleosides will be synthesized and Evalua

批准号：

7871755
项目类别：
资助金额：

$10.45万
财政年份：

2010
负责人：

Vishnumurthy R Hegde
依托单位：

ORGANIX, INC.

海外基金