Novel 2'- and 3'- Branched Carbocyclic Nucleosides will be synthesized and Evalua

新型 2- 和 3- 支链碳环核苷将被合成并评估

• 批准号: 8145654
• 负责人: Vishnumurthy R Hegde
• 金额: $ 10.35万
• 依托单位: ORGANIX, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-23 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8145654
• 关键词: Adenine; Adenosine Kinase; Antiviral Agents; Appearance; Binding; Binding Sites; Biological; Biological Assay; Bioterrorism; Carbohydrates; Carbon; Cells; Collaborations; Deamination; Development; Disease; Drug resistance; Elements; Enzymes; Evaluation; Exhibits; Future; Goals; Hepatitis B Virus; Hepatitis C virus; Herpesviridae; Homocysteine; Homocystine; Hydrogen Bonding; Hydrolase; In Vitro; Influenza; Influenza A Virus, H1N1 Subtype; Lead; Literature; Malignant Neoplasms; Modification; Molecular Conformation; Molecular Target; National Institute of Allergy and Infectious Disease; Nature; Nucleosides; Orthopoxvirus; Outcome; Pharmaceutical Preparations; Phosphorylation; Phosphotransferases; Positioning Attribute; Poxviridae; Property; Purines; Pyrimidine; Reporting; Research Project Grants; Ribose; Series; Severe Acute Respiratory Syndrome; Smallpox; Structure; Structure-Activity Relationship; Testing; Uracil; Variant; Viral; Virus; Virus Diseases; West Nile virus; Yellow Fever; adenosine deaminase; analog; aristeromycin; base; candidate identification; clinically relevant; cytosine analog; cytotoxicity; design; erythrose; flexibility; hydroxyl group; inhibitor/antagonist; molecular recognition; novel; nucleoside analog; public health relevance; purine; resistant strain; respiratory virus; sugar

DESCRIPTION (provided by applicant): The emergence of new viral diseases such as HCV, SARS, West Nile virus, H1N1 influenza, increased threat of bioterrorism using smallpox and appearance of new viral strains resistant to existing drugs warrants development of new medications. The goal of this proposal is to discover new antiviral candidates to treat such diseases by modifying a lead carbocyclic nucleoside analog. New analogs synthesized will be tested for antiviral activity against a wide array of viruses. PUBLIC HEALTH RELEVANCE: The goal of this proposal is to discover new antiviral candidates to treat new viral diseases such as HCV, SARS, West Nile virus, H1N1 influenza, and bioterrorism agent smallpox. The proposed research project also focuses on the development of new medications to viral strains resistant to existing drugs by modifying a lead carbocyclic nucleoside analog.

描述（由申请人提供）：HCV、SARS、西尼罗河病毒、H1N1流感等新型病毒性疾病的出现，天花生物恐怖主义威胁的增加，以及对现有药物具有耐药性的新病毒株的出现，都需要开发新的药物。本提案的目标是发现新的抗病毒候选药物，通过修饰铅碳环核苷类似物来治疗此类疾病。新合成的类似物将用于测试对多种病毒的抗病毒活性。