Novel 2'- and 3'- Branched Carbocyclic Nucleosides will be synthesized and Evalua

新型 2- 和 3- 支链碳环核苷将被合成并评估

• 批准号: 7871755
• 负责人: Vishnumurthy R Hegde
• 金额: $ 10.45万
• 依托单位: ORGANIX, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-23 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7871755
• 关键词: Nucleosides; novel

DESCRIPTION (provided by applicant): The emergence of new viral diseases such as HCV, SARS, West Nile virus, H1N1 influenza, increased threat of bioterrorism using smallpox and appearance of new viral strains resistant to existing drugs warrants development of new medications. The goal of this proposal is to discover new antiviral candidates to treat such diseases by modifying a lead carbocyclic nucleoside analog. New analogs synthesized will be tested for antiviral activity against a wide array of viruses. PUBLIC HEALTH RELEVANCE: The goal of this proposal is to discover new antiviral candidates to treat new viral diseases such as HCV, SARS, West Nile virus, H1N1 influenza, and bioterrorism agent smallpox. The proposed research project also focuses on the development of new medications to viral strains resistant to existing drugs by modifying a lead carbocyclic nucleoside analog.

描述(申请人提供)：新的病毒疾病的出现，如丙型肝炎病毒、非典、西尼罗河病毒、H1N1流感、使用天花的生物恐怖主义威胁的增加以及对现有药物具有抗药性的新病毒株的出现，需要开发新的药物。这项提议的目标是通过修改一种先导碳环核苷类似物来发现治疗此类疾病的新的抗病毒候选药物。新合成的类似物将被测试对多种病毒的抗病毒活性。 公共卫生相关性：这项提案的目标是发现新的抗病毒候选药物来治疗新的病毒疾病，如丙型肝炎病毒、SARS、西尼罗河病毒、H1N1流感和生物恐怖主义制剂天花。拟议的研究项目还侧重于通过修改一种先导碳环核苷类似物来开发对现有药物具有抗药性的病毒株的新药。