Sociocultural Factors and BRCA Genetic Counseling for Diverse Latinas

鉴于越来越多的证据表明遗传性乳腺癌和/或卵巢癌（HBOC）大大增加了某些家庭的癌症风险（1;2），这些高危妇女接受遗传咨询以赋予她们挽救生命的信息至关重要。不幸的是，研究表明，拉丁美洲人，美国人口增长最快的部分，是所有种族群体中最不可能寻求遗传咨询和随后的HBOC检测（3-5）。拟议的探索性定性R 03旨在确定解释拉丁裔在寻求BRCA遗传咨询HBOC的高风险妇女谁以前没有经历过咨询的代表性不足的因素。在我们的适应性行为预测综合模型的指导下，（图1），具体目的是探索和记录：1）在纽约市（NYC）具有HBOC家族史的不同高危拉丁裔人群中，对BRCA遗传咨询的信念和态度; 2）社会文化因素及其对不同高危拉丁裔人群中BRCA遗传咨询信念和态度的影响，包括：a）文化信仰和价值观; B）文化适应和文化适应压力; c）社会支持; d）乳腺癌和/或卵巢癌的个人和家族史;以及e）组织因素，包括社会经济地位和获得医疗护理的机会。这些信息将有助于指导未来制定文化上适当的干预计划，以增加拉丁美洲人参与乳腺癌和/或卵巢癌易感性的遗传咨询。 公共卫生相关性： 项目叙述拟议的探索性研究将确定解释遗传性乳腺癌和/或卵巢癌（HBOC）遗传咨询中拉丁裔代表性不足的因素。这一定性信息将有助于指导未来制定文化上适当的干预计划，以增加拉丁美洲人参与乳腺癌和/或卵巢癌易感性的BRCA遗传咨询，从而寻求减少这一人群中的健康差距。

DESCRIPTION (provided by applicant): Project Summary Given the mounting evidence that hereditary breast and/or ovarian cancer (HBOC) substantially increases cancer risk in some families (1;2), it is critical that such high-risk women receive genetic counseling to empower them with life-saving information. Unfortunately, research suggests that Latinas, the fastest growing segment of the U.S. population, are the least likely of all ethnic groups to seek genetic counseling and subsequent testing for HBOC (3-5). The proposed exploratory qualitative R03 seeks to determine factors that explain the under-representation of Latinas in seeking BRCA genetic counseling for HBOC among high-risk women who have not previously undergone counseling. Guided by our Adapted Integrative Model of Behavioral Prediction (Figure 1), the specific aims are to explore and document: 1) Beliefs and attitudes about BRCA genetic counseling among diverse, high-risk Latinas with family histories suggestive of HBOC in New York City (NYC); 2) Sociocultural factors and their influence on beliefs and attitudes about BRCA genetic counseling among diverse, high-risk Latinas including: a) cultural beliefs and values; b) acculturation and acculturative stress; c) social support; d) personal and family history of breast and/or ovarian cancer; and e) organizational factors, including socioeconomic status and access to medical care. This information will help guide the future development of culturally-appropriate intervention programs to increase Latinas' participation in genetic counseling for breast and/or ovarian cancer susceptibility. PUBLIC HEALTH RELEVANCE: Project Narrative The proposed exploratory research will determine factors that explain the under-representation of Latinas in genetic counseling for hereditary breast and/or ovarian cancer (HBOC). This qualitative information will help guide the future development of culturally-appropriate intervention programs to increase Latinas' participation in BRCA genetic counseling for breast and/or ovarian cancer susceptibility and therefore seek to reduce the health disparity witnessed in this population group.