Maternal obesity, weight gain and the black-white disparity in stillbirth

描述（由申请人提供）：死产是一个研究不足的问题，在世界范围内造成了巨大的疾病负担。在美国，2005年报告了近26,000例死产，几乎等于当年的婴儿死亡人数。美国黑人在怀孕20周时每1000名新生儿中有11.13名胎儿死亡，这与美国白人的4.79名胎儿死亡率形成鲜明对比。今天，白色和黑人妇女之间死产发生率的持久差异的原因在很大程度上仍然未知。然而，一种可能性可能与孕妇怀孕前和怀孕期间的体重有关。 我们建议测试的假设，极端的母亲体重之前和怀孕期间有助于死产的黑白差距。我们的具体目标是：（1）确定母亲孕前体重指数（BMI）和孕期体重增加对产前死胎风险的独立和联合作用。(2)评估母亲妊娠前BMI和妊娠期间体重增加对产前死产的黑白差异的贡献。(3)评价母体妊娠前BMI和妊娠期间体重增加（模式和总增加）以及由病理生理学贡献者或原因定义的产前死产亚型之间的独立和联合相关性。为了实现这些具体目标，我们将使用宾夕法尼亚州匹兹堡Magee妇女医院（1989年至2009年）的172，290例单胎分娩人群进行病例队列研究，其中包括估计879例产前死产。死胎病例将通过州胎儿死亡记录和医院分娩数据库来确定。由7名母胎医学专家组成的陪审团审查病历，将确认产前死胎，并使用现代分类系统确定其可能的原因。我们将通过围产期病理学家对所有死胎的胎盘组织学检查来确定导致死胎的病理生理因素和途径。对于研究中的所有妊娠，我们将使用通过病历审查确定的整个妊娠期间测量的体重数据补充分娩数据库中的现有信息。怀孕期间的体重增加将通过两种方式进行检查：妊娠期体重增加的模式和总体重增加高于，低于和低于修订后的2009年IOM体重增加建议（这包括怀孕期间体重减轻或无体重增加的具体检查）。我们的创新方法定义妊娠期体重增加的充分性，研究体重增加的模式，并分配死产的原因，将避免错误分类，并提供线索的机制连接孕前体重和体重增加胎儿死亡率。这项新的，具有成本效益的研究建立在现有文献的基础上，并通过使用创新的方法来充分探索妊娠前体重和体重增加这两个潜在的可改变因素对胎儿死亡的黑白差异的贡献。 公共卫生相关性：这项工作意义重大，因为美国胎儿死亡率的种族差异和肥胖症的流行是当今公共卫生中最关键的问题之一，我们的研究结果将推动这些领域的发展。这些结果可能揭示新的预防选择，可以降低医疗保健成本，并改善新生儿的生存和健康。

DESCRIPTION (provided by applicant): Stillbirth is an understudied problem that imposes a tremendous burden of disease worldwide. In the United States nearly 26,000 stillbirths were reported in 2005, almost equaling the number of infant deaths that year. U.S. blacks experienced 11.13 fetal deaths at e20 weeks gestation per 1000 births, which is in stark contrast to the fetal death rate of 4.79 among U.S. whites. The reasons for the enduring disparity in stillbirth incidence rates today between white and black woman remain largely unknown. One possibility, however, may be related to maternal weight before and during pregnancy. We propose to test the hypothesis that extremes of maternal weight before and during pregnancy contribute to the black-white disparity in stillbirth. Our specific aims are (1) To determine the independent and joint contribution of maternal prepregnancy body mass index (BMI) and weight gain during pregnancy to the risk of antepartum stillbirth. (2) To evaluate the contribution of maternal pregravid BMI and weight gain during pregnancy to the black-white disparity in antepartum stillbirth. (3) To evaluate the independent and joint association between maternal pregravid BMI and weight gain during pregnancy (pattern and total gain) and subtypes of antepartum stillbirth defined by pathophysiologic contributors or causes. To achieve these specific aims, we will conduct a case-cohort study using a population of 172,290 singleton deliveries at Magee- Womens Hospital in Pittsburgh, PA (1989 to 2009), which includes an estimated 879 antepartum stillbirths. Cases of stillbirth will be identified through state fetal death records and a hospital delivery database. Medical record review by a jury of 7 maternal-fetal medicine specialists will confirm antepartum stillbirth and define its likely cause(s) using a contemporary classification system. We will identify pathophysiologic contributors and pathways to stillbirth with a perinatal pathologist's examination of placental histology from all stillbirths. For all pregnancies in the study, we will supplement existing information in the delivery database with data on measured weights throughout gestation ascertained through medical record review. Weight gain during pregnancy will be examined two ways: pattern of gestational weight gain and total weight gain above, within, and below the revised 2009 IOM weight gain recommendations (this includes a specific examination of weight loss or no weight gain during pregnancy). Our innovative methods for defining gestational weight gain adequacy, studying pattern of weight gain, and assigning causes of stillbirth will avoid misclassification and provides clues into mechanisms linking prepregnancy weight and weight gain to fetal mortality. This novel, cost-efficient study builds upon and extends existing literature by using innovative methods to fully explore the contribution of pregravid weight and weight gain-two potentially modifiable factors-to black-white disparities in fetal death. PUBLIC HEALTH RELEVANCE: This work is significant because the racial disparity in fetal mortality and the epidemic of obesity in the U.S. are among the most critical problems in public health today, and our results will move these fields forward. These results may reveal new options for prevention that could reduce health care costs as well as improve survival and health of newborns.