Associations between Non-8-Carbon-Chain Perfuoroalkyl Acids and Serum Lipid, Live

非 8 碳链全氟烷基酸与活血清脂质之间的关联

• 批准号: 8115125
• 负责人: Stephanie J Frisbee
• 金额: $ 18.13万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8115125
• 关键词: Abbreviations; Accounting; Acids; Alanine Transaminase; Alkaline Phosphatase; Alkanesulfonates; Ammonium; Animals; Aspartate Transaminase; Bilirubin; Blood Urea Nitrogen; Blood specimen; C10; Carbon; Chemicals; Child; Clinical; Clinical Data; Cohort Studies; Communities; Creatinine; Data; Diagnostic; European Union; Funding; Gamma-glutamyl transferase; HDL-triglyceride; Half-Life; Health; High Density Lipoprotein Cholesterol; Human; LDL Cholesterol Lipoproteins; Lactate Dehydrogenase; Learning; Length; Life; Lipids; Liver; Low-Density Lipoproteins; Manufacturer Name; Measures; Mission; Names; Ohio; Outcome; Participant; Peripheral; Physiology; Plasticizers; Process; Reader; Regulation; Renal function; Research; Rivers; Safety; Sampling; Serum; United States; Uric Acid; Washington; Water Supply; Wetting Agents; Work; World War II; base; carcinogenesis; cohort; court; drinking water; human population study; indexing; liver function; man; manufacturing process; perfluorodecanoic acid; perfluorohexane; perfluorooctane sulfonate; programs; public drinking; public health relevance; total measurement Bilirubin

DESCRIPTION (provided by applicant): Perfluoroalkyl acids (PFAAs) are a class of man-made compounds developed after World War II for use as plasticizers, wetting agents, and as emulsifiers during industrial manufacturing processes. Two of the most common PFAAs are the 8-carbon chain chemicals perfluorooctanoic acid (PFOA or C8) and perfluorooctane sulfonate (PFOS or C8 sulfonate [C8S]). Recent, growing concern about possible health effects of PFAAs is the result of evidence that: PFAAs have a long half-life and environmental persistence; animal studies suggesting that PFAAs have deleterious effects, including carcinogenesis, and other disruptions to normal physiology; evidence of their widespread presence in human sera; and human population studies that have provided early evidence for potential exposure- related health effects. In the United States, the EPA- led PFOA Stewardship Program aims to eliminate PFOA from all emissions and products by 2015. In the European Union, the use of PFOS and derivatives was stopped in 2000 and banned in 2008, though PFOA use remains largely unregulated. As a result of this regulation, industrial manufacturers and users of PFOA or PFOS have needed to develop alternate chemicals and processes, and non-8-carbon chain PFAAs have emerged as replacement chemicals. However, almost no publically available scientific evidence exists regarding the human or environmental safety of these chemicals. The primary objective of this proposal is to determine the associations between non-8-carbon perfluoroalkyl acids (PFAAs) and serum parameters of lipid, liver, and kidney function in children. We are requesting funding to perform secondary analysis on data collected as part of the C8 Health Project, a community cohort study with 69,030 participants including more than 12,000 children. For the convenience of readers of this application, the following table summarizes the key abbreviations used throughout this application: Perfluoroalkyl Acids (PFAA) Abbreviation Full Name Carbon Length PFHxA Perfluorohexanoic acid C6 PFHS Ammonium perfluorohexane sulfonate C6S/C6 Sulfonate PFHpA Perfluoroheptanoic acid C7 PFOA Perfluorooctanoic acid C8 PFOS Perfluorooctane sulfonate acid C8S/C8 Sulfonate PFNA Perfluorononanoic acid C9 PFDA Perfluorodecanoic acid C10 Clinical Health Parameters Abbreviation Full Name LDL Cholesterol Low-density lipoprotein cholesterol HDL Cholesterol High-density lipoprotein cholesterol AlkPhos Alkaline Phosphatase ALT Alanine aminotransferase AST Aspartate aminotransferase BiliDirect Direct Bilirubin BiliTotal Total Bilirubin GGT Gamma glutamyltransferase LDH Lactate dehydrogenase BUN Blood urea nitrogen PUBLIC HEALTH RELEVANCE: NARRATIVE The primary objective of this proposal is to determine the associations between non-8-carbon perfluoroalkyl acids (PFAAs) and serum parameters of lipid, liver, and kidney function in children. We are requesting funding to perform secondary analysis on data collected as part of the C8 Health Project, a community cohort study with 69,030 participants, including more than 12,000 children, created pursuant to the pre-trial settlement of a class action lawsuit filed after PFOA contamination of drinking water supplies along the mid-Ohio River valley.

描述（由申请人提供）：全氟烷基酸（PFAA）是第二次世界大战后开发的一类人造化合物，在工业生产过程中用作增塑剂、润湿剂和乳化剂。两种最常见的全氟辛酸是8碳链化学品全氟辛酸（PFOA或C8）和全氟辛烷磺酸（PFOS或C8磺酸盐[C8 S]）。最近，人们越来越关注全氟辛酸对健康可能产生的影响，这是因为有证据表明：全氟辛酸具有较长的半衰期和环境持久性;动物研究表明全氟辛酸具有有害作用，包括致癌作用和对正常生理的其他干扰;有证据表明其广泛存在于人类血清中;以及人群研究提供了与接触有关的潜在健康影响的早期证据。在美国，EPA领导的PFOA管理计划旨在到2015年消除所有排放和产品中的PFOA。在欧洲联盟，全氟辛烷磺酸及其衍生物的使用于2000年停止，并于2008年被禁止，但全氟辛酸的使用在很大程度上仍不受管制。由于这一规定，全氟辛酸或全氟辛烷磺酸的工业制造商和用户需要开发替代化学品和工艺，非8碳链全氟辛酸已成为替代化学品。然而，关于这些化学品对人类或环境的安全性，几乎不存在任何可获得的科学证据。本提案的主要目的是确定儿童非8碳全氟烷基酸（PFAA）与血脂、肝脏和肾脏功能的血清参数之间的关系。我们正在申请资金对作为C8健康项目的一部分收集的数据进行二次分析，该项目是一项社区队列研究，有69，030名参与者，其中包括12，000多名儿童。为了方便本申请的读者，下表总结了贯穿本申请使用的关键缩写：全氟烷基酸（PFAA）缩写全称碳长度PFHxA全氟己酸C6 PFHS全氟己烷磺酸铵C6 S/C6磺酸盐PFHpA全氟庚酸C7 PFOA全氟辛酸C8 PFOS全氟辛烷磺酸C8 S/C6磺酸盐C8磺酸盐PFNA全氟壬酸C9 PFDA全氟癸酸C10临床健康参数缩写全名LDL胆固醇低密度脂蛋白胆固醇HDL胆固醇高-密度脂蛋白胆固醇碱性磷酸酶丙氨酸氨基转移酶丙氨酸氨基转移酶天门冬氨酸氨基转移酶胆红素直接直接胆红素总胆红素GGT γ-谷氨酰转移酶LDH乳酸脱氢酶BUN血尿素氮 公共卫生关系： 本研究的主要目的是确定非8碳全氟烷基酸（PFAAs）与儿童血脂、肝脏和肾脏功能的血清参数之间的关系。我们正在申请资金，对作为C8健康项目的一部分收集的数据进行二次分析，该项目是一项社区队列研究，有69，030名参与者，其中包括12，000多名儿童，该研究是根据在PFOA污染沿着俄亥俄河流域中部的饮用水供应后提起的集体诉讼的审前和解而创建的。