Associations between Non-8-Carbon-Chain Perfuoroalkyl Acids and Serum Lipid, Live

说明(申请人提供)：全氟烷基酸(PFAA)是二战后开发的一类人造化合物，用于工业生产过程中的增塑剂、润湿剂和乳化剂。两种最常见的PFAA是全氟辛酸(全氟辛酸或C8)和全氟辛烷磺酸(全氟辛烷磺酸或C8磺酸盐[C8S])。最近，人们越来越关注PFAA可能对健康造成的影响，这是以下证据的结果：PFAA具有较长的半衰期和环境持久性；动物研究表明PFAA具有有害影响，包括致癌和对正常生理的其他干扰；有证据表明它们广泛存在于人类血清中；以及人类人口研究提供了与暴露相关的潜在健康影响的早期证据。在美国，美国环保局牵头的全氟辛烷磺酸管理计划旨在到2015年从所有排放和产品中消除全氟辛酸。在欧洲联盟，全氟辛烷磺酸及其衍生产品的使用于2000年停止，并于2008年被禁止，尽管全氟辛烷磺酸的使用在很大程度上仍然不受管制。由于这一规定，工业制造商和全氟辛烷磺酸或全氟辛烷磺酸的用户需要开发替代化学品和工艺，非8碳链PFAA已成为替代化学品。然而，关于这些化学品对人类或环境的安全性，几乎没有公开可用的科学证据。这项建议的主要目的是确定非8碳全氟烷基酸(PFAA)与儿童血清脂质、肝和肾功能参数的相关性。我们正在申请资金，对作为C8健康项目一部分收集的数据进行二级分析，C8健康项目是一项社区队列研究，有69,030名参与者，其中包括12,000多名儿童。为了方便读者阅读本申请，下表总结了本申请中使用的关键缩写：全氟烷基酸(PFAA)全称碳长PFHxA全氟己酸C6 PFHS全氟己烷磺酸铵C6S/C6磺酸盐PFHpA全氟庚酸C7 PFOA全氟辛酸C8 PFOS全氟辛烷磺酸C8S/C8全氟辛烷磺酸C8S/C8全氟辛酸PFNA全氟辛酸C9 PFDA全氟己酸C10临床健康参数缩写全名全称胆固醇碱性磷酸转氨酶高密度脂蛋白低密度脂蛋白胆固醇总胆红素直接甘氨酸甘油转氨酶总胆红素甘氨酸甘油转氨酶 公共卫生相关性： 这项建议的主要目标是确定非8碳全氟烷基酸(PFAA)与儿童血清脂质、肝和肾功能参数之间的关系。我们正在申请资金，以对作为C8健康项目一部分收集的数据进行二次分析。C8健康项目是一项社区队列研究，有69,030名参与者，其中包括12,000多名儿童，该研究是根据全氟辛烷磺酸污染俄亥俄河谷中部饮用水供应后提起的集体诉讼的预审和解而创建的。

DESCRIPTION (provided by applicant): Perfluoroalkyl acids (PFAAs) are a class of man-made compounds developed after World War II for use as plasticizers, wetting agents, and as emulsifiers during industrial manufacturing processes. Two of the most common PFAAs are the 8-carbon chain chemicals perfluorooctanoic acid (PFOA or C8) and perfluorooctane sulfonate (PFOS or C8 sulfonate [C8S]). Recent, growing concern about possible health effects of PFAAs is the result of evidence that: PFAAs have a long half-life and environmental persistence; animal studies suggesting that PFAAs have deleterious effects, including carcinogenesis, and other disruptions to normal physiology; evidence of their widespread presence in human sera; and human population studies that have provided early evidence for potential exposure- related health effects. In the United States, the EPA- led PFOA Stewardship Program aims to eliminate PFOA from all emissions and products by 2015. In the European Union, the use of PFOS and derivatives was stopped in 2000 and banned in 2008, though PFOA use remains largely unregulated. As a result of this regulation, industrial manufacturers and users of PFOA or PFOS have needed to develop alternate chemicals and processes, and non-8-carbon chain PFAAs have emerged as replacement chemicals. However, almost no publically available scientific evidence exists regarding the human or environmental safety of these chemicals. The primary objective of this proposal is to determine the associations between non-8-carbon perfluoroalkyl acids (PFAAs) and serum parameters of lipid, liver, and kidney function in children. We are requesting funding to perform secondary analysis on data collected as part of the C8 Health Project, a community cohort study with 69,030 participants including more than 12,000 children. For the convenience of readers of this application, the following table summarizes the key abbreviations used throughout this application: Perfluoroalkyl Acids (PFAA) Abbreviation Full Name Carbon Length PFHxA Perfluorohexanoic acid C6 PFHS Ammonium perfluorohexane sulfonate C6S/C6 Sulfonate PFHpA Perfluoroheptanoic acid C7 PFOA Perfluorooctanoic acid C8 PFOS Perfluorooctane sulfonate acid C8S/C8 Sulfonate PFNA Perfluorononanoic acid C9 PFDA Perfluorodecanoic acid C10 Clinical Health Parameters Abbreviation Full Name LDL Cholesterol Low-density lipoprotein cholesterol HDL Cholesterol High-density lipoprotein cholesterol AlkPhos Alkaline Phosphatase ALT Alanine aminotransferase AST Aspartate aminotransferase BiliDirect Direct Bilirubin BiliTotal Total Bilirubin GGT Gamma glutamyltransferase LDH Lactate dehydrogenase BUN Blood urea nitrogen PUBLIC HEALTH RELEVANCE: NARRATIVE The primary objective of this proposal is to determine the associations between non-8-carbon perfluoroalkyl acids (PFAAs) and serum parameters of lipid, liver, and kidney function in children. We are requesting funding to perform secondary analysis on data collected as part of the C8 Health Project, a community cohort study with 69,030 participants, including more than 12,000 children, created pursuant to the pre-trial settlement of a class action lawsuit filed after PFOA contamination of drinking water supplies along the mid-Ohio River valley.