Project 3: Mechanisms of In Utero BPA Exposure on Fetal Gonad Development
项目3:子宫内BPA暴露对胎儿性腺发育的机制
基本信息
- 批准号:8208663
- 负责人:
- 金额:$ 7.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-12-01 至 2012-11-30
- 项目状态:已结题
- 来源:
- 关键词:AdultAffectAnimal ModelAnimalsBehaviorBindingBiologicalBiological ModelsCellsChemicalsChild DevelopmentCognitiveCryptorchidismDefectDevelopmentDiethylstilbestrolDiseaseDoseEmbryoEndocrine DisruptorsEstrogen Nuclear ReceptorEstrogen ReceptorsEstrogensExhibitsExposure toFemaleFertilityFetusGenesGeneticGenetic ModelsGenetic PolymorphismGenetic VariationGerm CellsGoalsGonadal structureGrantHormonesHumanIn VitroIndividualKnock-outKnockout MiceLeadLifeLinkMethodsModelingMusOrganOvaryPerinatal ExposurePlasmaPlasticsPredisposing FactorPredispositionPregnant WomenProcessProductionReproductionResearch Project GrantsRodentSerumSignal PathwaySomatic CellStagingStructureTestingTestisTransgenic MiceTransgenic OrganismsUmbilical Cord BloodWorkbasebisphenol Acarcinogenesiscognitive functiondesignestrogenic activityestrogenic endocrine disruptorfetalgonad functionhuman femalein uteroinsightmalemalformationmanmouse modelnoveloffspringoverexpressionphthalatesreceptorreproductivereproductive developmentreproductive functionresearch studyresponsesextool
项目摘要
The main objective of this research project is to understand how in utero Bisphenol A (BPA) exposure affects
fetal gonadal development and reproduction in adulthood in mice. In utero exposure to estrogenic endocrine
disruptors such as diethylstilbestrol (DES) is known to cause sex organ malformation, reproductive
carcinogenesis, and fertility defects in both male and female in humans and rodents. Based on DES studies,
it is proposed that in utero exposure to other endocrine disruptors, particularly those that work through
estrogen receptors, may lead to reproductive diseases in adulthood. BPA, a chemical used in synthesis of
plastics, exhibits estrogenic activities and deleterious effects on reproduction when given to adult rodents.
BPA is detected in serum of pregnant women, umbilical cord blood, and fetal plasma, indicating that
developing fetuses are exposed to BPA. Although effects of BPA on adult reproductive organs have been
studied extensively, impacts of in utero BPA exposure particularly on fetal gonadal development are not well
understood. In vitro experiments have suggested that BPA, similar to other estrogenic compounds, could
bind to classical nuclear estrogen receptors (ERa or p), which are present in fetal mouse gonads. Therefore,
the main goal of this Research Project is to test the hypothesis that in utero exposure to BPA causes
gonadal defects in fetal and adult life via ERs. We design two specific aims to 1) investigate whether loss of
ERa or B in fetal gonads render embryos insensitive to deleterious effects of BPA in reproductive funcstions
and 2) study whether overexpression of ER increases the susceptibility of embryos to in utero exposure of
BPA. The proposed experiments take advantage of the power of transgenic mouse models in combination of
classic toxicological approaches. This project will not only provide animal models to test hypotheses that
human models cannot, but also complementary information to interpret results of other components of the
formative grant.
本研究项目的主要目的是了解子宫内双酚A (BPA)暴露对胎儿的影响
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Humphrey Hung-Chang Yao其他文献
NR2F2 regulation of interstitial cell fate in the embryonic mouse testis and its impact on differences of sex development
NR2F2 对胚胎小鼠睾丸间质细胞命运的调控及其对性发育差异的影响
- DOI:
10.1038/s41467-025-59183-6 - 发表时间:
2025-04-29 - 期刊:
- 影响因子:15.700
- 作者:
Martín Andrés Estermann;Sara A. Grimm;Abigail S. Kitakule;Karina F. Rodriguez;Paula R. Brown;Kathryn McClelland;Ciro M. Amato;Humphrey Hung-Chang Yao - 通讯作者:
Humphrey Hung-Chang Yao
Humphrey Hung-Chang Yao的其他文献
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{{ truncateString('Humphrey Hung-Chang Yao', 18)}}的其他基金
Project 3: Mechanisms of In Utero BPA Exposure on Fetal Gonad Development
项目3:子宫内BPA暴露对胎儿性腺发育的机制
- 批准号:
7846644 - 财政年份:2010
- 资助金额:
$ 7.93万 - 项目类别:
Unveil a Novel Pathway in Mammalian Ovary Development
揭示哺乳动物卵巢发育的新途径
- 批准号:
7534810 - 财政年份:2005
- 资助金额:
$ 7.93万 - 项目类别:
Unveil a Novel Pathway in Mammalian Ovary Development
揭示哺乳动物卵巢发育的新途径
- 批准号:
6863582 - 财政年份:2005
- 资助金额:
$ 7.93万 - 项目类别:
Unveil a Novel Pathway in Mammalian Ovary Development
揭示哺乳动物卵巢发育的新途径
- 批准号:
7001251 - 财政年份:2005
- 资助金额:
$ 7.93万 - 项目类别:
Unveil a Novel Pathway in Mammalian Ovary Development
揭示哺乳动物卵巢发育的新途径
- 批准号:
7149971 - 财政年份:2005
- 资助金额:
$ 7.93万 - 项目类别:
Unveil a Novel Pathway in Mammalian Ovary Development
揭示哺乳动物卵巢发育的新途径
- 批准号:
7326853 - 财政年份:2005
- 资助金额:
$ 7.93万 - 项目类别:
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