Neural Mechanisms of Social Emotion Regulation

社会情绪调节的神经机制

• 批准号: 8068355
• 负责人: JAMES A COAN
• 金额: $ 32.38万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-30 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8068355
• 关键词: Address; Adolescent; Affect; Age; Animals; Autistic Disorder; Behavior; Biomedical Research; Brain; Characteristics; Communities; Conflict (Psychology); Corpus striatum structure; Cues; Dimensions; Emotional; Emotional Stress; Emotions; Empathy; Epidemiology; Ethnic group; Face; Familiarity; Fragile X Syndrome; Friends; Functional Magnetic Resonance Imaging; Hand; Human; Image; Incentives; Individual; Knowledge; Laboratories; Link; Major Depressive Disorder; Measures; Monitor; Mood Disorders; Neurodevelopmental Disorder; Neurosciences; Participant; Personality; Personality Traits; Public Health; Regulation; Rewards; Sampling; Schizophrenia; Seeds; Shock; Social Behavior; Social Interaction; Social Sciences; Spin Labels; Support System; System; Time; Trust; Williams Syndrome; Work; abuse neglect; affection; blood oxygen level dependent; coping; design; emotion regulation; experience; in vivo; neural circuit; neuromechanism; nonhuman primate; peer; relating to nervous system; sex; social; social attachment; social neuroscience; young adult

DESCRIPTION (provided by applicant): Although neural systems thought to underlie social bonding and the social regulation of emotion are increasingly well documented in animals and nonhuman primates, the candidate neural mechanisms responsible for these effects in humans remain speculative. Moreover, very little work to date has sought specifically to identify how social affiliation and emotion circuits function in a context that combines social interaction with externally generated emotional stress. In the proposed study, we plan to closely examine human social contact, attachment, and the social regulation of emotion, in vivo, using functional magnetic resonance imaging (fMRI). We will monitor functional brain activity related to physical social contact, physical contact from a familiar other, and the social regulation of both threat responding and empathy, across four conceptually linked studies utilizing 124 participants drawn from a larger (n = 172) normative sample of young adults (ages 24 to 28) whose social behaviors, parental and peer social experiences, and personality characteristics have been assessed annually from the ages of 13-22. This proposal will greatly expand our knowledge of how social bonding, familiarity, and soothing are instantiated neurally, as well as how social contact and soothing regulate neural systems supporting emotional responding. Moreover, the proposed design will allow us to evaluate the moderating influences on these neural systems of relationship characteristics such as status, quality and closeness; individual characteristics such as broad dimensions of emotion-regulatory personality, attachment and overt social behavior; and historical factors such as levels of parental affection versus abuse and neglect, and levels of adolescent peer integration versus rejection. A deeper understanding of the neural circuitry underlying social behavior and the social regulation of emotional responding promises not only to contribute to basic progress in neuroscience, biomedical research, social science, public health, and epidemiology, but also to our understanding of, and efficacy in treating, a number of severely debilitating affective and neurodevelopmental disorders such as Autism, Fragile X, William's Syndrome, Schizophrenia and even Major Depression.

描述（由申请人提供）：尽管被认为是社会联系和情感的社会调节的神经系统在动物和非人类灵长类动物中越来越充分地证明了候选神经机制在人类中的候选神经机制仍然是投机性的。此外，迄今为止，很少有人寻求专门的工作来确定在将社会互动与外部产生的情感压力相结合的环境中如何发挥作用。在拟议的研究中，我们计划使用功能磁共振成像（fMRI）仔细检查体内的人类社会接触，依恋和情绪的社会调节。我们将监控与身体社会接触，熟悉的其他人的身体接触有关的功能性大脑活动以及对威胁反应和同理心的社会调节，在四项概念上相关的研究中，利用124名参与者从较大的（n = 172）年轻人的年轻人样本（24至28岁）（年龄24至28岁）中得出，其社交行为，养生社会经历和人的社会经历和人格特征是对13岁的人的经历。该建议将大大扩展我们对社会联系，熟悉和舒缓的知识，以及如何实例化神经，以及社会接触和舒缓如何调节支持情感反应的神经系统。此外，拟议的设计将使我们能够评估对这些关系特征的神经系统（例如地位，质量和亲密关系）的调节影响；个人特征，例如情绪调节性格，依恋和公开社会行为的广泛维度；以及诸如父母情感与虐待和忽视的水平等历史因素，以及青少年同伴整合与拒绝的水平。对社会行为和情感反应的社会调节的更深入了解不仅有望为神经科学，生物医学研究，社会科学，公共卫生和流行病学的基本进步做出贡献重度抑郁症。