Motivational control of appetitive memory

食欲记忆的动机控制

• 批准号: 8033681
• 负责人: Scott Waddell
• 金额: $ 35.83万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-08 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8033681
• 关键词: Address; Adenylate Cyclase; Adrenergic Receptor; Affect; Behavior; Behavioral; Binding; Biological Models; Biological Neural Networks; Brain; Communication; Coupled; Cyclic AMP; Data; Disease; Drosophila genus; Food; G-Protein-Coupled Receptors; GTP-Binding Proteins; Genes; Genetic; Genome; Goals; Health; Human; Hunger; Knowledge; Learning; Life; Ligands; Mediating; Memory; Mental disorders; Modeling; Molecular; Mood Disorders; Motivation; Nervous system structure; Neurons; Neuropeptides; Norepinephrine; Octopamine; Orthologous Gene; Outcome; Pathway interactions; Performance; Process; Receptor Activation; Reporting; Retrieval; Role; Rutabaga; Satiation; Second Messenger Systems; Signal Pathway; Signal Transduction; Stimulus; System; Technology; Testing; Therapeutic; Time; Work; addiction; extracellular; feeding; fly; long term memory; memory encoding; memory retrieval; mutant; neural circuit; neuromechanism; neuropeptide F; neuropeptide Y; new technology; octopamine receptor; phosphoric diester hydrolase; quantum; receptor; relating to nervous system; research study; second messenger

DESCRIPTION (provided by applicant): We use our memories to guide our life. For the most part, we are able to effectively use memory to direct behavior as, and when, we want to. For example, although you know where your fridge is, you do not go there unless you are hungry. However, in certain disease-states, such as affective disorders and addiction, motivational control goes awry and behavior becomes compulsive. The long-term goal of this proposal is to understand how the brain systems encoding memory integrate with the neural networks that determine motivation. We will specifically investigate how the `motivation to feed' network interacts with appetitive memory (formation and retrieval) to guide food-seeking behavior at the appropriate time. We use the fruit fly Drosophila as our model system because it can learn, it has a relatively simple brain and it is amenable to a sophisticated genetic approach. We will use the most up to date technology available in Drosophila to manipulate and elucidate the role of monoaminergic and Neuropeptide Y signaling systems in the fly brain that have conserved counterparts in the mammalian brain. We therefore expect that these studies will have a major impact on strategies for human mnemonic therapy, addiction and a wide variety of mental disorders. PUBLIC HEALTH RELEVANCE The ability to appropriately direct behavior using our memories is something we take for granted. However, in certain disease-states, such as affective disorders and addiction, our motivational control goes awry and behavior runs amok. This proposal will explore how the brain systems encoding memory integrate with the neural networks that determine motivation. Our work will provide fundamental knowledge of how conserved cell signaling systems motivate behavioral memory performance and we expect these studies will provide relevant therapeutic avenues against a wide variety of mental disorders.

描述(申请人提供)：我们用我们的记忆来指导我们的生活。在很大程度上，我们能够有效地使用记忆在我们想要的时间和时间指导行为。例如，虽然你知道你的冰箱在哪里，但你不会去那里，除非你饿了。然而，在某些疾病状态下，如情感障碍和成瘾，动机控制会出错，行为变得强迫。这项提议的长期目标是了解大脑系统如何编码记忆与决定动机的神经网络相结合。我们将具体研究“觅食动机”网络如何与食欲记忆(形成和提取)相互作用，以在适当的时间指导觅食行为。我们使用果蝇作为我们的模型系统，因为它可以学习，它的大脑相对简单，而且它服从复杂的遗传方法。我们将使用果蝇中可用的最新技术来操纵和阐明单胺类和神经肽Y信号系统在果蝇大脑中的作用，这些信号系统在哺乳动物的大脑中具有保守的对应物。因此，我们预计这些研究将对人类助记治疗、成瘾和各种精神障碍的策略产生重大影响。与公共健康相关，利用我们的记忆适当地指导行为的能力是我们理所当然的。然而，在某些疾病状态下，如情感障碍和成瘾，我们的动机控制会出现偏差，行为失控。这项提议将探索大脑系统如何编码记忆与决定动机的神经网络相结合。我们的工作将提供关于保守的细胞信号系统如何激发行为记忆表现的基础知识，我们预计这些研究将提供针对各种精神障碍的相关治疗途径。