WIRELESS REMOTE ABDOMINAL PRESSURE SYSTEM: DEVELOPING A MORE COMPREHENSIVE UNDERS

无线远程腹压系统：开发更全面的下

基本信息

批准号：
8097331
负责人：
INGRID E NYGAARD
金额：
$ 35.76万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-15 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8097331
关键词：
Affect American Area Biomedical Engineering Bladder Cardiovascular system Clinic Clinical Clinical Data Collaborations Computer software Computers Coupling Data Databases Development Devices Disease Electrical Engineering Elements Engineering Equipment Etiology Exercise Exertion Future Goals Gold Health Benefit High Prevalence Hour Household Incidence Individual Investigation Laboratories Life Lifting Location Measurement Measures Methods Monitor Occupational Participant Pelvic Floor Disorders Pelvic floor structure Pelvis Performance Physical activity Play Process Production Proxy Questionnaires Records Rectum Recurrence Reproducibility Research Research Personnel Risk Factors Role Scientist Self-Administered Strenuous Exercise Surveys System Techniques Technology Testing Time Translating Translations Tube Urodynamics Vagina Wireless Technology Woman abdominal pressure base data exchange design diaries experience improved indexing innovation instrument interest minimally invasive modifiable risk next generation pressure prototype public health relevance response sensor stressor tool

项目摘要

DESCRIPTION (provided by applicant): Pelvic floor disorders affect one in four American women. Few modifiable risk factors have been identified that might reduce the incidence or progression of pelvic floor disorders. Popular wisdom and scant clinical data suggest that strenuous activity causes or promotes pelvic floor disorders. Given the health benefits of activity, women should be encouraged to be maximally active unless there is scientific evidence to the contrary. Existing physical activity instruments are largely designed to assess cardiovascular exertion and are validated using activity diaries, accelerometers, and step counters. Such measures may not accurately measure activities that increase loading on the pelvic floor (such as lifting). After researching available technologies, we concluded that a tool to understand how physical activities impact abdominal pressure in the real world does not exist. Over the past 18 months, our interdisciplinary team of bioengineers, urogynecologists, electrical engineers, and exercise scientists developed and validated the performance of a prototype for an intravaginal abdominal pressure sensor that accurately measures pressure in the upper vagina, an easily accessible space that records pressures similar to the true intraabdominal pressure. In this proposal, we plan first to further develop an integrated system (the "WRAPS", Wireless Remote Abdominal Pressure System) to monitor intraabdominal pressure outside of the clinical setting. This system will consist of three key elements: an intravaginal pressure sensor with wireless data transmission capability, a small portable data monitoring and storage unit, and computer based data translation software for downloading and managing the pressure data. In a controlled exercise laboratory setting, we will then use intraabdominal pressure data generated by the WRAPS to determine the reproducibility of intraabdominal pressures measured during specific types of physical activity and will finalize development of a valid questionnaire that categorizes the magnitude of intraabdominal pressures during activities. Finally, in a real-world setting in which participants wear the intravaginal sensor during waking hours for four 1-week periods over the course of a year, we will characterize intraabdominal pressures experienced by women of varying degrees of habitual physical activity and, using WRAPS data as the gold standard, determine whether activity can be appropriately categorized in terms of pelvic loading by means of self-administered questionnaires, the current standard. Obtaining future evidence about the impact of physical stressors on pelvic floor disorders relies on our ability to measure the risk factor in question. This innovative translational collaboration will remove a critical barrier to progress in understanding the etiology of pelvic floor disorders in women. PUBLIC HEALTH RELEVANCE: The effect of strenuous physical activity on new or recurrent pelvic floor disorders is unknown. We developed an intravaginal pressure sensor to measure intraabdominal pressure. We will perfect the wireless technology needed to use the sensor remotely so that we can understand how different activities done during real world settings affect intraabdominal pressures and pelvic floor disorders.

描述（由申请人提供）：骨盆底疾病影响四分之一的美国女性。很少有可修改的危险因素可以降低骨盆底疾病的发生率或进展。流行的智慧和很少的临床数据表明，剧烈的活动会导致或促进骨盆底疾病。鉴于活动的健康益处，除非有科学证据相反，否则应鼓励妇女最大程度地活跃。现有的体育锻炼工具在很大程度上旨在评估心血管劳累，并使用活动日记，加速度计和步骤计数器进行验证。这样的措施可能无法准确测量增加骨盆底上负载的活动（例如举重）。在研究了可用的技术之后，我们得出的结论是，一种了解体育活动如何影响现实世界中的腹压力的工具。在过去的18个月中，我们的生物工程师，泌尿妇女学家，电气工程师和运动科学家的跨学科团队开发并验证了在阴道内腹部压力传感器上的原型表现，可准确测量阴道上的压力，可易于访问的空间，这是一个与真实内部压力相似的可及压力。在此提案中，我们首先计划进一步开发一个集成系统（“包裹”，无线远程腹压力系统），以监测临床环境外腹腔内压力。该系统将由三个关键要素组成：具有无线数据传输功能，小型便携式数据监视和存储单元以及用于下载和管理压力数据的基于计算机的数据翻译软件的小型数据传输功能，小型的可移植数据传输能力。然后，在受控的运动实验室环境中，我们将使用包裹产生的腹部压力数据来确定在特定体育锻炼期间测量的腹内压力的可重复性，并将最终确定有效的问卷的开发，以对活动期间腹腔内压力的幅度进行分类。 Finally, in a real-world setting in which participants wear the intravaginal sensor during waking hours for four 1-week periods over the course of a year, we will characterize intraabdominal pressures experienced by women of varying degrees of habitual physical activity and, using WRAPS data as the gold standard, determine whether activity can be appropriately categorized in terms of pelvic loading by means of self-administered questionnaires, the current standard.获得有关物理压力源对骨盆底疾病的影响的未来证据取决于我们测量有关危险因素的能力。这种创新的翻译合作将消除在理解女性骨盆底疾病的病因方面的关键障碍。公共卫生相关性：艰苦的体育锻炼对新的或经常性骨盆底疾病的影响尚不清楚。我们开发了一个阴道内压力传感器来测量腹部压力。我们将完善远程使用传感器所需的无线技术，以便我们可以理解现实世界中不同的活动如何影响腹内压力和骨盆底疾病。