Genetic Elements Controlling Blood Pressure

描述（由申请人提供）：在所有高血压患者中，有90%的人在不明原因的情况下发生高血压，也称为原发性高血压。尽管众所周知，遗传学在原发性高血压的易感性中起着重要作用，但导致原发性高血压的基因/遗传因素的身份仍在很大程度上未知，这是促进我们对原发性高血压病因学理解的最大限制因素。利用大鼠高血压遗传模型，我们已经确定了大鼠基因组中负责控制血压的区域。如果将该区域映射到单个遗传元件的分辨率，则可以用于查询与人类高血压病因相似的遗传元件。因此，我们建议的目的是在我们已经精细绘制的三个区域确定BP的遗传决定因素。我们的建议的意义在于，它可能处于揭示原发性高血压病因的新遗传因素的边缘。公共卫生启示：众所周知，遗传是导致高血压的一个重要因素，高血压会导致心血管相关疾病。本提案中描述的研究工作有助于改善我们目前对控制血压的基因身份的有限理解。通过成功完成所描述的工作所获得的知识有望确定以前未被怀疑引起高血压的遗传因素。

DESCRIPTION (provided by applicant): Among all the hypertensive subjects combined, >90% develop hypertension for no known reasons, also called as Essential hypertension. Although it is well known that genetics play a major role in conferring susceptibility to develop essential hypertension, the identities of the genes/genetic factors that are causally responsible for essential hypertension remaining largely unknown is the single biggest rate-limiting factor in advancing our understanding of the etiology of essential hypertension. Using a rat genetic model for hypertension, we have located regions on the rat genome as responsible for controlling BP. This region, if mapped to the resolution of single genetic elements, can then be utilized for querying similar genetic elements as causative of hypertension in humans. The aims of our proposal are to therefore identify the genetic determinants of BP on three regions that we have already fine-mapped. The significance of our proposal is that it is potentially on the verge of unraveling novel genetic factors in the etiology of Essential Hypertension. PUBLIC HEALTH REVELANCE: Genetics is well recognized to be an important factor that contributes to the development of hypertension, which leads to cardiovascular related illnesses. The research work described in this proposal pertains to improve our current, significantly limited understanding of the identities of genes that control blood pressure. Knowledge gained through successful completion of the work described is expected to identify genetic factors that have not been previously suspected to cause hypertension.