Administrative Core

项目总结（见说明）： 行政五核心的总体目的是确保该计划在科学、组织和运作方面的卓越性，以及实现NIEHS科学里程碑和目标的能力。核心将负责PNNL的工程纳米材料毒性计划的整体组织结构，行政活动和财政责任，并将确保所有研究都是完整的，并有适当的环境，安全和健康考虑和规划。 这些职责将通过以下目标来完成： 1)为决策过程、研究活动的规划、项目资金的有效管理以及项目的资源分配提供管理和行政支持结构; 2)促进跨学科的相互作用和协调的研究项目和研究核心内的程序，包括材料合成和材料表征; 3)协调统计分析和跨研究项目的实验数据建模和计划内的研究核心;和4）确保与NIEHS和更广泛的NIEHS纳米毒理学研究联盟的有效联络。 Admlnistrafive核心还将对跨项目、生物系统数据集成所需的生物统计资源和活动进行监督和优先级排序，并保持对开发工程危害识别和风险评估新方法的总体计划目标的关注 纳米材料

PROJECT SUMMARY (See instructions): The overall purpose of the Admlnistrafive Core is to ensure scientific, organizational and operational excellence ofthe Program and its ability to meet scientific milestones and objectives ofthe NIEHS. The Core will be responsible for overall organizational structure, administrative activities and fiscal responsibilities of the PNNL's Program for the Toxicity of Engineered Nanoniaterials, and will ensure all research is conducted with integrity and with appropriate environmental, safety and health considerations and planning. These responsibilities will be accomplished by the following Aims: 1) Provide a management and admlnistrative support structure for decision-making processes, planning of research activities, and efficient management of program funds, and resource allocation with the Program; 2) Promote cross-disciplinary interactions and coordination among the research projects and the research core within the Program, including material synthesis and materials characterization; 3) Coordinate statistical analysis and modeling of experimental data across research projects and the research core within the Program; and 4) Ensure effecfive liaison with NIEHS and the broader NIEHS nanotoxicology research consortium. The Admlnistrafive Core will also provide oversight and prioritization of biostatistical resources and activities needed for data integration across projects, biological systems, and to maintain focus of the overall Program goals of developing novel approaches for hazard identificafion and risk assessment for engineered nanomaterials.