Core A: Material Science Core

核心A：材料科学核心

• 批准号: 8067698
• 负责人: DONALD BAER
• 金额: $ 15.52万
• 依托单位: BATTELLE PACIFIC NORTHWEST LABORATORIES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-28 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8067698
• 关键词: Address; Artificial nanoparticles; Arts; Behavior; Biological; Biosensor; Chemicals; Chemistry; Collection; Department of Energy; Dyes; Ecology; Environment; Fluorescent Dyes; Goals; In Vitro; Individual; Laboratories; Measures; Methods; Modeling; Molecular; Nature; Oxides; Precipitation; Process; Property; Quantitative Structure-Activity Relationship; Research; Research Project Grants; Science; Silicon Dioxide; Structure; Surface; Time; Work; biological systems; ceric oxide; design; experience; in vivo; interest; iron oxide; member; nanoparticle; particle; programs; time use; tool

The essential objective of the Materials Science Core is to provide well defined and specifically designed nanoparticles (NPs) that allow the objectives of the three research projects to be addressed. Although materials preparafion for any biological or toxicological study is not necessarily a simple task, the challenges of assuring that the physicochemical properties and structural arrangement of engineered NPs used for biological studies are well established at the fime of actual use are significant. It is increasingly recognized that individual NPs can be altered by the method of analysis, can change structure or chemical state in different environments, and may change as a function of time. In addition, properties of particles and collections of particles are infiuenced by aggregation, the presence of impurities and the nature of deliberate or adventitious coatings. Therefore, in addition to preparing NPs of the desired size, composition and structure, and surface chemistry, it is essential to confirm the nature of the particles at the time of use and to have an understanding of how the particle properties and particle distributions vary with time in the environments of interest. Three different oxide NPs, cerium oxide (ceria), iron oxide, and silica have been identified as the 'primary' particles to be examined in the biological studies. Members ofthe Materials Science research team have experience with the synthesis and characterization of NPforms of these three materials. Our experience with the synthesis and characterization of particles of the desired size (and size distribution), composifion and surface chemistry (or surface functionalization) will be used to achieve the goals of the Core. The team has the background and experience to design and prepare oxide NPs that will enable the PNNL U19 Program to accomplish their three research objectives; Aim 1. Synthesize and characterize the 'primary' nanoparticles desired for biological studies with well defined physicochemical properties. Aim 2. Design and synthesis of nanoparticles optimized for counfing and tracking in biological environments. Aim 3. Understand the impact of different environmental conditions on the fime-dependent properties ofthe primary and coated nanoparticles.

材料科学核心的基本目标是提供明确定义和专门设计的纳米颗粒（NP），以实现三个研究项目的目标。尽管用于任何生物学或毒理学研究的材料制备不一定是一项简单的任务，但确保用于生物学研究的工程化NP的物理化学性质和结构排列在实际使用时得到充分确立的挑战是显著的。人们越来越认识到，单个NP可以通过分析方法改变，可以在不同环境中改变结构或化学状态，并且可以作为时间的函数而改变。此外，颗粒的性质和颗粒的聚集受到聚集、杂质的存在和故意的性质的影响。 或外来涂层。因此，除了制备具有所需尺寸、组成和结构以及表面化学的纳米颗粒外，还必须在使用时确认颗粒的性质，并了解颗粒性质和颗粒分布在目标环境中如何随时间变化。三种不同的氧化物NP，氧化铈（二氧化铈）、氧化铁和二氧化硅已经被合成。 被确定为生物学研究中要检查的“主要”颗粒。材料科学研究团队的成员具有这三种材料的NP形式的合成和表征的经验。我们在合成和表征所需尺寸（和尺寸）的颗粒方面的经验 分布）、复合和表面化学（或表面功能化）将用于实现核心的目标。该团队拥有设计和制备氧化物纳米颗粒的背景和经验，这将使PNNL U19计划能够实现他们的三个研究目标：目标1。合成和表征具有明确物理化学性质的生物学研究所需的“初级”纳米颗粒。目标2.生物环境中计数和跟踪用纳米粒子的优化设计与合成。目标3。了解不同环境条件对原始和包覆纳米颗粒的薄膜依赖性的影响。