Animal Imaging Core
动物成像核心
基本信息
- 批准号:7982959
- 负责人:
- 金额:$ 8.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-01 至 2015-07-31
- 项目状态:已结题
- 来源:
- 关键词:Animal TechniciansAnimalsBiodistributionBiologicalBiomedical ResearchBlood VesselsBrain NeoplasmsCommitCyclotronsDevelopmentDisease ProgressionEquipmentFacultyFundingGoalsHousingImageImage AnalysisImaging TechniquesImaging technologyLeadMagnetic Resonance ImagingMeasuresMethodsMonitorNanotechnologyNon-Small-Cell Lung CarcinomaOpticsPreparationProtocols documentationRadiochemistryRecruitment ActivityResearch InfrastructureResearch PersonnelResourcesSecureSiteTechnical ExpertiseTreatment EfficacyTumor VolumeUltrasonographyVascular Permeabilitiesbasebiological systemsdensityimaging modalityimprovedin vivoindexinginsightmembernanoparticlenoveloperationoptical imagingprogramssingle photon emission computed tomographysuccesstooltreatment response
项目摘要
Title: Animal Imaging Core
Recent advances in small animal imaging have substanfially improved our ability to gain insights into disease progression without altering the biological systems. The small animal imaging facility at UNC currentiy houses nine major imaging equipments, including MRI (2), PET/CT (1), CT (1), SPECT (1), optical imaging (3), and ultrasound (1). In addition, skillful technical staff members to maintain and operate the imaging equipments and animal technicians to facilitate animal preparation for imaging and monitoring during imaging are available. Leveraging on these impressive resources, the small animal imaging (SAI) core aims to provide advanced imaging technology to facilitate the proposed projects. Specifically, two major imaging tasks will be carried out for the proposed projects, including to depict biodistribution of nanoparticles (Projects 1, 2, and 3) and to monitor and evaluate therapeutic efficacy of the proposed nanoparticles or treatment regirnens (Projects 2, 3, and 4) using imaging methods. To accomplish the former task, both PET and optical imaging methods will be developed to more efficiently and accurately provide biodistribution informafion. For the latter task, four imaging modalities, including optical, CT, PET, and MRI will be used to monitor therapeufic efficacy. Finally, while the imaging capability in the small animal imaging facility is already impressive, our insfitution has committed additional funds to further augment the imaging program at UNC, including the establishment of an on-site cyclotron facility and the associated radiochemistry lab and the development of imaging registrafion approaches for mulfimodality imaging using microCT, MRI, and PET
(Projects 2, 3 and 4). Together, we believe that the available technical expertise and well established infrastructure in the small animal imaging facility will greatly facilitate the success ofthe proposed projects.
标题:动物成像核心
小动物成像的最新进展大大提高了我们在不改变生物系统的情况下了解疾病进展的能力。小动物成像设施目前拥有九种主要成像设备,包括MRI(2),PET/CT(1),CT(1),SPECT(1),光学成像(3)和超声(1)。此外,有熟练的技术人员维护和操作成像设备,有动物技术人员协助动物准备成像和成像期间的监测。利用这些令人印象深刻的资源,小动物成像(SAI)核心旨在提供先进的成像技术,以促进拟议的项目。具体而言,将为拟议项目执行两项主要成像任务,包括描绘纳米颗粒的生物分布(项目1,2和3)以及使用成像方法监测和评估拟议纳米颗粒或治疗方案的治疗效果(项目2,3和4)。为了完成前一项任务,将开发PET和光学成像方法,以更有效和准确地提供生物分布信息。对于后一项任务,将使用四种成像方式,包括光学、CT、PET和MRI来监测治疗效果。最后,虽然小动物成像设备的成像能力已经令人印象深刻,但我们的研究机构已投入额外资金,以进一步扩大在北京的成像计划,包括建立现场回旋加速器设施和相关的放射化学实验室,以及开发使用microCT、MRI和PET进行多模态成像的成像配准方法。
(项目2、3和4)。总之,我们相信,现有的技术专长和完善的基础设施,在小动物成像设施将大大促进成功的拟议项目。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Weili Lin的其他文献
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{{ truncateString('Weili Lin', 18)}}的其他基金
Characterizing morphological and hemodynamic characteristics of human brain perivascular spaces with aging using 7T MRI
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9183206 - 财政年份:2016
- 资助金额:
$ 8.63万 - 项目类别:
A Joint Segmentation and Registration Framework for Early Brain Development Study
早期大脑发育研究的联合分割和注册框架
- 批准号:
9038395 - 财政年份:2015
- 资助金额:
$ 8.63万 - 项目类别:
Siemens Tim Trio 3T Whole Body MR Scanner
西门子 Tim Trio 3T 全身磁共振扫描仪
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7497828 - 财政年份:2008
- 资助金额:
$ 8.63万 - 项目类别:
Characterization of Normal Brain Development Using Parallel MRI
使用并行 MRI 表征正常大脑发育
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7414364 - 财政年份:2007
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$ 8.63万 - 项目类别:
Characterization of Normal Brain Development Using Parallel MRI
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- 批准号:
7816927 - 财政年份:2007
- 资助金额:
$ 8.63万 - 项目类别:
Characterization of Normal Brain Development Using Parallel MRI
使用并行 MRI 表征正常大脑发育
- 批准号:
7235881 - 财政年份:2007
- 资助金额:
$ 8.63万 - 项目类别:
Characterization of Normal Brain Development Using Parallel MRI
使用并行 MRI 表征正常大脑发育
- 批准号:
8064643 - 财政年份:2007
- 资助金额:
$ 8.63万 - 项目类别:
Characterization of Normal Brain Development Using Parallel MRI
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- 批准号:
7615584 - 财政年份:2007
- 资助金额:
$ 8.63万 - 项目类别:
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