Small Animal Imaging Core Facility

小动物成像核心设施

• 批准号: 8340291
• 负责人: Weili Lin
• 金额: $ 22.43万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-23 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8340291
• 关键词: Animal Model; Animals; Archives; Bioluminescence; Cancer Center; Cancer Center Support Grant; Cancer Etiology; Carbon Nanotubes; Contract Services; Core Facility; Cyclotrons; Data; Development; Equipment; Fluorescence; Frequencies; Funding; Goals; Grant; Home environment; Housing; Human Resources; Image; Image Analysis; Imaging Device; Imaging Techniques; Imaging technology; Magnetic Resonance Imaging; Molecular; Monitor; North Carolina; Online Systems; PET/CT scan; Picture Archiving and Communication System; Positron-Emission Tomography; Preparation; Radiochemistry; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resolution; Services; Site; Specimen; System; Therapeutic; Training and Education; Ultrasonography; anticancer research; base; cost; design; flexibility; fluorescence imaging; imaging modality; improved; in vivo; lung imaging; member; multimodality; novel; operation; optical imaging; protocol development; single photon emission computed tomography; tomography; tool

Small Animal Imaging Core Facility The goal of the Small Animal Imaging (SAI) core is to provide advanced animal imaging services, including imaging acquisition and image analysis tools that will facilitate cancer research at UNC and beyond. The imaging ability provided by the core allowed sophisticated monitoring of animal models, especially for studies focusing on cancer etiology and molecular therapeutics. The SAI core currently houses 10 imaging devices, including two 3T Siemens MR scanners, a 9.4T Bruker small animal MR scanner, a GE Explore animal PET/CT scanner, a UNC-designed high resolution SPECT scanner, a high resolution microCT for specimens (SCANCO), a high frequency ultrasound system (VisualSonics), and three IVIS optical imaging systems with capability for both bioluminescence and fluorescence imaging. Three additional imaging devices will be added to the SAI core in 2010: a GE SPECT/CT, a Fluorescence Molecular Tomography system, and a novel carbon nanotube-based CT. The SAI core currently supports 54 research projects. The SAI core requests $115,958 in CCSG funds, representing 12% its operating costs; 63% of the core's use is allocated to Cancer Center members. The increase in funding is requested to support the additional personnel and service contracts for new imaging equipment. For the next funding cycle, the SAI core proposes two major goals: expanding imaging, education and training services and developing multimodality imaging technology and analysis.

小动物成像核心设施 小动物成像 (SAI) 核心的目标是提供先进的动物成像服务，包括成像采集和图像分析工具，以促进北卡罗来纳大学及其他地区的癌症研究。核心提供的成像能力可以对动物模型进行复杂的监测，特别是针对癌症病因学和分子治疗的研究。 SAI核心目前包含10个成像设备， 包括两台 3T 西门子 MR 扫描仪、一台 9.4T Bruker 小动物 MR 扫描仪、一台 GE Explore 动物 PET/CT 扫描仪、一台 UNC 设计的高分辨率 SPECT 扫描仪、一台高分辨率标本显微 CT (SCANCO)、一台高频超声系统 (VisualSonics) 和三台具有生物发光和荧光成像功能的 IVIS 光学成像系统。三个额外的成像设备将 2010 年，SAI 核心添加了以下设备：GE SPECT/CT、荧光分子断层扫描系统和新型碳纳米管 CT。 SAI核心目前支持54个研究项目。 SAI 核心请求 CCSG 资金 115,958 美元，相当于其运营成本的 12%； 63% 的核心使用量分配给癌症中心成员。请求增加资金是为了支持新成像设备的额外人员和服务合同。对于下一个融资周期，SAI 核心提出了两个主要目标：扩大成像、 教育和培训服务以及开发多模态成像技术和分析。