Immunological prevention of cysticercosis and hydatid disease

囊尾蚴病和包虫病的免疫预防

• 批准号: nhmrc : 350279
• 负责人: Prof Marshall Lightowlers
• 金额: $ 34.01万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/immunological-prevention-cysticercosis-hydatid-disease/98747
• 关键词: Immunological; prevention; cysticercosis; hydatid; disease

Cysticercosis and hydatid disease are caused by infections with the larval stages of tapeworm parasites. These infections cause substantial morbidity and mortality throughout the world, but particularly in developing countries. They are zoonotic diseases, being transmitted to humans from animals. This project aims to develop practical vaccines to assist with the prevention of both cysticercosis and hydatid disease in humans. The vaccines will be used in the parasites' natural animal hosts, thereby breaking the parasite life-cycle and preventing the diseases being passed to humans. Substantial preliminary research has been undertaken by the applicant, including completion of successful preliminary vaccine trials. This project will optimise the vaccines and complete initial field trials in countries with high rates of disease transmission.

囊虫病和包虫病是由感染幼虫期的绦虫寄生虫引起的。这些感染在世界各地造成相当大的发病率和死亡率，尤其是在发展中国家。它们是人畜共患的疾病，通过动物传染给人类。该项目旨在开发实用的疫苗，以帮助预防人类囊虫病和包虫病。这些疫苗将用于寄生虫的自然动物宿主，从而打破寄生虫的生命周期，防止疾病传播给人类。申请者进行了大量的初步研究，包括完成了成功的疫苗初步试验。该项目将优化疫苗，并在疾病传播率较高的国家完成初步现场试验。