Infectious Diseases of the Nervous System: Pathogenesis and Worldwide Impact

描述（由申请人提供）：我们提议召开一次关于“神经系统传染病：发病机制和世界影响”的会议，因为嗜神经病原体在全世界，特别是在热带和发展中国家，对人类的痛苦和疾病负担造成了重大影响。会议的范围将空前广泛，将聚集由这些病原体引起的主要疾病的优秀专家，如脑疟疾和结核病、脑膜炎、儿童和成人艾滋病毒相关神经认知障碍、几种类型的病毒性脑炎、昏睡病、麻风病、囊虫病引起的癫痫以及脊髓灰质炎和狂犬病等重新出现/持续存在的病毒性疾病。第一次会议将讨论病原体传播到神经系统的分子机制，它们的多样性和对特定神经细胞的趋向性。神经系统通过先天免疫对入侵者作出反应，先天免疫与适应性免疫相结合，可能导致受感染细胞死亡、病毒潜伏期或病原体清除。接下来的会议将集中于人类疾病的临床表现和发病机制，讨论正在进行的研究，以阐明神经系统损伤的本质。会议将以一个关于新诊断工具和治疗前景的会议结束。该项目的主要目标之一是吸引许多年轻学员，特别是来自受这些疾病影响最严重的国家的学员，并创建一个讨论论坛，激励他们开展关于神经系统感染的临床和研究活动，扩大全世界的合作研究努力。我们汇集了一份对该领域作出杰出贡献的发言者名单（32人接受了我们的邀请），使我们的会议有了独特的成功机会。巴斯德研究所将是2008年9月10日至13日在巴黎举行的这次活动的一个非常方便的地点。我们建议，这次会议将通过扩大对这些毁灭性神经系统疾病的临床方面和发病机制的认识，并促进其预防、诊断和治疗方面的进展，来推进NINDS的使命。这是一份关于“神经系统传染病：发病机制和世界影响”会议的提案。会议将于2008年9月10日至13日在法国巴黎巴斯德研究所举行。会议将汇集对脑型疟疾和结核病、脑膜炎、艾滋病毒相关神经认知障碍和病毒性脑炎、昏睡病、麻风病和囊虫病等研究作出杰出贡献的发言者名单。

DESCRIPTION (provided by applicant): We propose to hold a conference on "Infectious Diseases of the Nervous System: Pathogenesis and World Impact" because neurotropic pathogens contribute significantly to human suffering and disease burden throughout the world, particularly in tropical and developing countries. The conference will have an unprecedented broad scope, gathering excellent experts on major diseases caused by these pathogens such as cerebral malaria and tuberculosis, meningitis, HIV-associated neurocognitive disorders of children and adults, several types of viral encephalitis, sleeping sickness, leprosy, epilepsy caused by cysticercosis and re-emerging/persisting viral diseases such as poliomyelitis and rabies. The first conference sessions will discuss the molecular mechanisms of pathogen spreading to the nervous system, their diversity and tropism for specific neural cells. The nervous system responds to the invader by innate immunity which, combined with adaptive immunity, may lead to infected cell death, viral latency or clearance of the pathogen. The following sessions will center on human disease clinical manifestations and pathogenesis, discussing ongoing studies to elucidate the nature of the nervous system damage. The conference will conclude with a session on new diagnostic tools and therapeutic prospects. One of the major goal of this project is to attract many young trainees particularly from countries most affected by these diseases and to create a forum of discussion that will inspire them in their clinical and research activities on infections of the nervous system, expanding collaborative research efforts worldwide. We have assembled a roster of speakers who have made outstanding contributions to the field (32 have accepted our invitation) giving our conference a unique chance of success. The Pasteur Institute site will be a very convenient venue for this event in Paris, September 10 to 13, 2008. We propose that this conference will advance the mission of NINDS by expanding the knowledge on clinical aspects and pathogenesis of these devastating neurological diseases and promoting progress in their prevention, diagnostic and therapies. This is a proposal for conference on "Infectious Diseases of the Nervous System: pathogenesis and world impact". The conference will take place at the Pasteur Institute in Paris, France, September 10 to 13, 2008. It will gather a roster of speakers who have made outstanding contribution to research on cerebral malaria and tuberculosis, meningitis, HIV-associated neurocognitive disorders and viral encephalitis, sleeping sickness, leprosy and cysticercosis.