Infectious Diseases of the Nervous System: Pathogenesis and Worldwide Impact

描述（由申请人提供）：我们建议举行一次关于“神经系统传染病：发病机制和世界影响”的会议，因为嗜神经性病原体对全世界人类的痛苦和疾病负担有重大贡献，特别是在热带和发展中国家。这次会议的范围将空前广泛，聚集了关于这些病原体引起的主要疾病的优秀专家，如脑型疟疾和肺结核、脑膜炎、儿童和成人与艾滋病毒有关的神经认知障碍、几种病毒性脑炎、昏睡病、麻风病、囊虫病引起的癫痫以及脊髓灰质炎和狂犬病等重新出现/持续存在的病毒性疾病。第一次会议将讨论病原体传播到神经系统的分子机制，它们的多样性和对特定神经细胞的向性。神经系统通过先天免疫对入侵者作出反应，先天免疫与适应性免疫相结合，可能导致感染细胞死亡、病毒潜伏或病原体清除。以下会议将集中在人类疾病的临床表现和发病机制，讨论正在进行的研究，以阐明神经系统损伤的性质。会议最后将举行一次关于新的诊断工具和治疗前景的会议。该项目的主要目标之一是吸引特别是来自受这些疾病影响最严重的国家的许多年轻受训人员，并建立一个讨论论坛，激励他们开展关于神经系统感染的临床和研究活动，扩大全世界的合作研究努力。我们汇集了一批在该领域做出杰出贡献的发言者（32人接受了我们的邀请），这给了我们会议一个独特的成功机会。巴斯德研究所的场地将是2008年9月10日至13日在巴黎举行的这一活动的一个非常方便的地点。我们建议，本次会议将通过扩大对这些毁灭性神经系统疾病的临床方面和发病机制的知识，并促进其预防，诊断和治疗的进展，推进NINDS的使命。这是一个关于“神经系统传染病：发病机制和世界影响”会议的建议。会议将于2008年9月10日至13日在法国巴黎的巴斯德研究所举行。它将收集一份发言者名册，这些发言者在脑型疟疾和肺结核、脑膜炎、与艾滋病毒有关的神经认知障碍和病毒性脑炎、昏睡病、麻风病和囊虫病的研究方面作出了杰出贡献。

DESCRIPTION (provided by applicant): We propose to hold a conference on "Infectious Diseases of the Nervous System: Pathogenesis and World Impact" because neurotropic pathogens contribute significantly to human suffering and disease burden throughout the world, particularly in tropical and developing countries. The conference will have an unprecedented broad scope, gathering excellent experts on major diseases caused by these pathogens such as cerebral malaria and tuberculosis, meningitis, HIV-associated neurocognitive disorders of children and adults, several types of viral encephalitis, sleeping sickness, leprosy, epilepsy caused by cysticercosis and re-emerging/persisting viral diseases such as poliomyelitis and rabies. The first conference sessions will discuss the molecular mechanisms of pathogen spreading to the nervous system, their diversity and tropism for specific neural cells. The nervous system responds to the invader by innate immunity which, combined with adaptive immunity, may lead to infected cell death, viral latency or clearance of the pathogen. The following sessions will center on human disease clinical manifestations and pathogenesis, discussing ongoing studies to elucidate the nature of the nervous system damage. The conference will conclude with a session on new diagnostic tools and therapeutic prospects. One of the major goal of this project is to attract many young trainees particularly from countries most affected by these diseases and to create a forum of discussion that will inspire them in their clinical and research activities on infections of the nervous system, expanding collaborative research efforts worldwide. We have assembled a roster of speakers who have made outstanding contributions to the field (32 have accepted our invitation) giving our conference a unique chance of success. The Pasteur Institute site will be a very convenient venue for this event in Paris, September 10 to 13, 2008. We propose that this conference will advance the mission of NINDS by expanding the knowledge on clinical aspects and pathogenesis of these devastating neurological diseases and promoting progress in their prevention, diagnostic and therapies. This is a proposal for conference on "Infectious Diseases of the Nervous System: pathogenesis and world impact". The conference will take place at the Pasteur Institute in Paris, France, September 10 to 13, 2008. It will gather a roster of speakers who have made outstanding contribution to research on cerebral malaria and tuberculosis, meningitis, HIV-associated neurocognitive disorders and viral encephalitis, sleeping sickness, leprosy and cysticercosis.