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Theranostic Magnetic Nanostructures for the Molecular Imaging of Cancer

用于癌症分子成像的治疗诊断磁性纳米结构

基本信息

批准号：
7983868
负责人：
Thomas J Meade
金额：
$ 19.7万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7983868
关键词：
Area Biochemical Biocompatible Biological Sciences Cancer Model Catheters Cell Culture Techniques Cell Line Cellular Stress Chemistry Clinical Coculture Techniques Contrast Media Drug Formulations Funding Gene Expression Goals Grant Image Implant In Vitro Injection of therapeutic agent Label Lesion Magnetism Malignant Neoplasms Malignant neoplasm of central nervous system Malignant neoplasm of pancreas Modification Molecular Monitor Nanostructures Nanotechnology Normal Cell Physiological Preparation Property Reporter Reporting Research Personnel Resistance Safety Signal Transduction Surface Synthesis Chemistry Techniques Testing Therapeutic Therapeutic Effect Time Toxic effect Training Transgenic Organisms Treatment Efficacy Xenograft Model base biomaterial compatibility cancer therapy cellular imaging design experience graduate student improved in vivo in vivo Model medical specialties migration molecular imaging molecular marker mortality nanomaterials oncology outcome forecast response tool tumor

项目摘要

The main objective of this project is to develop new theranostic probes that exploit the rapidly advancing field of nanotechnology. We will utilize the extraordinary magnetic properties of nanostructures for simultaneous imaging and treatment of cancer. Further, our bioactivated probes can be used for imaging cell fate and migration, gene expression, and secondary messenger activation in vivo. The rationale for this approach is that noninvasive molecular imaging is ideal for correlating the status of the tumor to treatment efficacy. Molecular imaging is an important tool for biological sciences and the clinical areas. In order to maximize the impact of these techniques, sensitive contrast agents must be developed that are also functional. We have demonstrated the ability of bioactivated MR contrast agents to act as in vivo biochemical reporters. Our project design is to use bioactivated probes attached to magnetic nanostructure (MNS) platforms for reporting on physiological properties of lesions and tumors. Imaging the MNS in conjunction with cancer treatments over time, we will be able to evaluate the molecular response of the cancer to the therapeutic. We have assembled a team of investigators whose specialties include synthetic and materials chemistry, nanostructure preparation, molecular imaging and oncology. Four graduate students of all levels with experience in at least one of these areas (molecular imaging, synthetic chemistry, nanostructure preparation) will be trained during the five years of funding supplied by this grant

该项目的主要目标是开发利用快速发展的纳米技术领域的新的治疗探头。我们将利用纳米结构的非凡磁性同时进行癌症成像和治疗。此外，我们的生物活性探针可以用于成像体内细胞的命运和迁移、基因表达和二次信使激活。这种方法的基本原理是，非侵入性分子成像是将肿瘤状态与治疗效果相关联的理想方法。分子成像是生物科学和临床领域的重要工具。为了最大限度地发挥这些技术的影响，必须开发出同时具有功能的敏感造影剂。我们已经证明了生物活性磁共振造影剂作为体内生化记者的能力。我们的项目设计是使用附着在磁性纳米结构(MNS)平台上的生物活性探针来报告病变和肿瘤的生理特性。随着时间的推移，结合癌症治疗对MNS进行成像，我们将能够评估癌症对治疗的分子反应。我们组建了一支研究团队，他们的专业包括合成和材料化学、纳米结构制备、分子成像和肿瘤学。四名在这些领域中至少有一个领域(分子成像、合成化学、纳米结构制备)有经验的所有级别的研究生将在这一助学金提供的五年资助期间接受培训。