Inhibition, Oscillations and Information Processing in Schizophrenia

Conte精神疾病神经科学中心（CCNMD）提供了一个高度互动的科学环境，整合了来自匹兹堡大学医学院和艺术与科学学院以及邻近的卡内基梅隆大学的多名研究人员的基础和临床研究活动。总的来说，CCNMD代表了广泛的专业知识，涵盖分子，系统，认知，计算和临床神经科学，提供了补充的方法来测试中心假设，即GABA神经元亚群中的分子改变的独特模式（病理学）引起皮层网络振荡中的保守干扰（病理生理学）是精神分裂症核心信息处理缺陷（临床综合征）的基础。拟议的5个项目得到行政、临床服务和诊断以及统计和数据管理核心的支持，研究1）在被认为产生振荡活动的皮层GABA神经元的不同子集中精神分裂症的分子异常（项目1-刘易斯）; 2）综合计算，电生理学和解剖学方法来确定细胞类型之间的关系，离体皮层GABA特异性神经传递和振荡（项目2-Ermentrout）; 3）GABA神经传递在皮层振荡中的作用，皮层振荡是由非人类灵长类动物的任务引起的，这些任务与精神分裂症中改变的信息处理域相同（项目3-Olson）; 4）精神分裂症中与某些皮层区域的激活改变和受损网络振荡有关的特定类型的信息处理障碍（项目4-菲利普斯）;和5）用于研究体内人类皮层GABA神经元功能的新PET成像工具的开发（项目5-马西斯）。这些项目的协同作用和双向相互作用促进了精神分裂症研究的转化方法，该方法旨在确定新的治疗干预措施的基于病理生理学的靶点，并开发可用于监测药物疗效的病理生理学生物标志物。 这样的干预。因此，拟议中的中心是一个多学科的努力，旨在测试一个机制的假设，以提高我们的理解的核心组成部分的疾病过程的精神分裂症。此外，该中心还提供1）丰富的培训和职业发展环境，使个人可以参与研究，将基础神经科学的方法和知识基础用于解决临床精神分裂症研究中的关键问题，2） 向更广泛的科学界和外行传播精神分裂症转化研究的重要性和从中获得的知识。

This Conte Center for the Neuroscience of Mental Disorders (CCNMD) offers a highly interactive scientific environment that integrates the basic and clinical research activities of multiple investigators from the University of Pittsburgh's Schools of Medicine and Arts and Sciences and the adjacent Carnegie Mellon University. Collectively, the CCNMD represents a broad array of expertise spanning molecular, systems, cognitive, computational and clinical neuroscience that provides complementary approaches to testing the central hypothesis that a distinctive pattern of molecular alterations in subpopulations of GABA neurons (pathology) gives rise to conserved disturbances in cortical network oscillations (pathophysiology) that underlie the core information processing deficits (clinical syndrome) of schizophrenia. The proposed 5 projects, supported by Administrative, Clinical Services and Diagnostics, and Statistics and Data Management Cores, examine 1) molecular abnormalities in schizophrenia in distinct subsets of cortical GABA neurons thought to generate oscillatory activity (Project 1-Lewis); 2) integrated computational, electrophysiological and anatomical approaches to determine the relationship between cell type-specific cortical GABA neurotransmission and oscillations in vitro (Project 2-Ermentrout); 3) the role of GABA neurotransmission in cortical oscillations elicited by tasks that tap in non-human primates the same information processing domains that are altered in schizophrenia (Project 3-Olson); 4) specific types of information processing disturbances in schizophrenia that are linked to altered activation of, and impaired network oscillations in, certain cortical regions (Project 4-Phillips); and 5) the development of new PET imaging tools for studying the function of human cortical GABA neurons in vivo (Project 5-Mathis). The synergism and bi-directional interactions of these projects facilitates a translational approach to schizophrenia research directing at identifying pathophysiology-based targets for novel therapeutic interventions and developing biomarkers of the pathophysiology that can be used to monitor the efficacy of such interventions. Thus, the proposed Center is a multi-disciplinary effort directed at testing a mechanistic hypothesis in order to improve our understanding of a core component of the disease process of schizophrenia. In addition, the Center provides 1) a rich environment for training and career development in which individuals can become involved in studies that bring the methods and knowledge base of basic neuroscience to address critical questions in clinical schizophrenia research, and 2) a mechanism for disseminating the importance of, and the knowledge gained from, translational studies of schizophrenia to the broader scientific and lay communities.