Information Routing in the Hippocampus via Gamma Oscillations
通过伽玛振荡在海马体中进行信息路由
基本信息
- 批准号:8645311
- 负责人:
- 金额:$ 3.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-01-01 至 2017-12-31
- 项目状态:已结题
- 来源:
- 关键词:AnimalsAreaAutistic DisorderBehavioralBrainBrain regionBuffersCellsCodeCognitionCognitiveCommunicationCommunications MediaComplexConflict (Psychology)ConfusionCouplingDiseaseEnvironmentExhibitsFaceFire - disastersFrequenciesGenerationsHealthHippocampus (Brain)HumanImpaired cognitionIndividualLeadLearningLinkLocationMeasuresMedialMemoryMethodsNeurobehavioral ManifestationsNeuronsPatternPhysiologyPlayProcessPropertyRattusRetrievalRodentRoleRouteSchizophreniaSensoryShort-Term MemorySocietiesSourceSymptomsTestingTimeVariantVisitVisual attentionbasecostcost effectiveentorhinal cortexexperiencehigh riskinsightmemory encodingmemory processmemory retrievalneural circuitnovelobject recognitionprospectiverelating to nervous systemresearch studyscreening
项目摘要
The brain is able to perform complex processes through communication across functionally distinct brain regions. Neural oscillations, or brain waves/rhythms, including those in the gamma frequency range (~25 ¿ 140 Hz), may play a critical role in this form of communication. Neural oscillations represent periodic, synchronous activity across large groups of neurons. When oscillations in one region are synchronous with oscillations in another, their neuronal activity is temporally aligned, and thus region-to-region communication is facilitated. In this way, oscillatory synchrony may gate the flow of information between specific regions of the brain, creating transient ensembles unique to given brain processes. Importantly, this modulation of connectivity is rapid, reversible, and independent of physical changes to the underlying circuitry. Recent evidence suggests that the hippocampus, a region central to memory function, may utilize gamma oscillations in this way. Gamma oscillations in the hippocampus occur as two variants ¿ a slow gamma form (~25 ¿ 55 Hz) and a fast gamma form (~65 ¿ 140 Hz). Each variant occurs at separate times and synchronizes anatomically distinct hippocampal sub-regions. Specifically, slow gamma links areas CA3 and CA1, a circuit implicated in memory retrieval, while fast gamma links the medial entorhinal cortex (MEC) and CA1, a circuit thought necessary for memory encoding. We therefore hypothesize that slow gamma synchrony enhances CA1 ¿ CA3 communication and is necessary for proper memory retrieval, while fast gamma synchrony enhances MEC ¿ CA1 communication and is necessary for proper memory encoding. This hypothesis will be tested by examining differences in oscillatory and single cell activity in the hippocampus during each memory function (retrieval and encoding). We expect to see enhanced fast gamma activity during memory encoding and enhanced slow gamma activity during memory retrieval. Specific Aim 1 will examine this hypothesis at the cellular level by measuring the activity of place cells, which represent the ¿where¿ component of memory. These cells exhibit unique firing properties during memory encoding vs. memory retrieval, providing a convenient method for determining the effects of slow and fast gamma on different memory functions. Specific Aim 2 will examine this hypothesis at the behavioral level by measuring fast and slow gamma activity during a simple learning task. The results of the proposed experiments are expected to provide insights into the link between oscillatory activity and complex brain function, and lead to a deeper understanding of the role of aberrant oscillations in the generation of cognitive dysfunction.
大脑能够通过跨功能不同的大脑区域的通信来执行复杂的过程。神经振荡,或脑电波/节律,包括伽马频率范围(~25 <$140 Hz)的脑电波/节律,可能在这种形式的通信中起着关键作用。神经振荡表示大群神经元之间的周期性同步活动。当一个区域的振荡与另一个区域的振荡同步时,它们的神经元活动在时间上对齐,从而促进区域与区域的通信。通过这种方式,振荡同步可以控制大脑特定区域之间的信息流,从而为特定的大脑过程创造出独特的短暂集合。重要的是,这种连接的调节是快速的,可逆的,并且独立于底层电路的物理变化。最近的证据表明,海马体,一个对记忆功能至关重要的区域,可能以这种方式利用伽马振荡。海马体中的伽马振荡以两种形式发生:慢伽马形式(~25 <$55 Hz)和快伽马形式(~65 <$140 Hz)。每种变异发生在不同的时间和解剖学上不同的海马子区域。具体来说,慢伽马连接区域CA 3和CA 1,这是一个涉及记忆提取的回路,而快伽马连接内侧内嗅皮层(MEC)和CA 1,这是一个被认为是记忆编码所必需的回路。因此,我们假设慢伽马同步增强CA 1 <$CA3通信,并且是正确的记忆检索所必需的,而快伽马同步增强MEC <$CA1通信,并且是正确的记忆编码所必需的。这一假设将通过检查在每个记忆功能(检索和编码)期间海马体中振荡和单细胞活性的差异来检验。我们希望在记忆编码过程中看到增强的快速伽马活动,在记忆检索过程中看到增强的缓慢伽马活动。具体目标1将在细胞水平上通过测量位置细胞的活动来检验这一假设,位置细胞代表记忆的“在哪里”成分。这些细胞在记忆编码与记忆检索过程中表现出独特的放电特性,为确定慢速和快速伽马对不同记忆功能的影响提供了一种方便的方法。具体目标2将通过测量简单学习任务期间的快速和慢速伽马活动来在行为层面检验这一假设。拟议实验的结果预计将为振动活动与复杂大脑功能之间的联系提供深入见解,并使人们更深入地了解异常振动在认知功能障碍产生中的作用。
项目成果
期刊论文数量(0)
专著数量(0)
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Kevin W. Bieri其他文献
Kevin W. Bieri的其他文献
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{{ truncateString('Kevin W. Bieri', 18)}}的其他基金
Information Routing in the Hippocampus via Gamma Oscillations
通过伽玛振荡在海马体中进行信息路由
- 批准号:
8762249 - 财政年份:2014
- 资助金额:
$ 3.23万 - 项目类别:
Information Routing in the Hippocampus via Gamma Oscillations
通过伽玛振荡在海马体中进行信息路由
- 批准号:
8985690 - 财政年份:2014
- 资助金额:
$ 3.23万 - 项目类别:
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