Research Administration Core, Human DNA Samples Bank, Animal Models, & Databases

研究管理核心、人类 DNA 样本库、动物模型、

• 批准号: 8097940
• 负责人: Emmanuel J Mignot
• 金额: $ 34.22万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8097940
• 关键词: Adherence; Administrator; Animal Genetics; Animal Model; Animals; Antigen-Presenting Cells; Award; Brain; Canis familiaris; Cataplexy; Cerebrospinal Fluid; Clinic; Communication; Complex; DNA; DNA Library; Data; Data Base Management; Databases; Discipline; Disease; Dissection; Documentation; Ensure; Epidemiology; Faculty; Funding; Genes; Genetic; Goals; Grant; Guidelines; HLA Antigens; Human; Human Genetics; Lead; Leadership; Maintenance; Modeling; Mus; Narcolepsy; Patients; Policies; Prevalence; Principal Investigator; Program Research Project Grants; Psychiatry; Publications; Rattus; Reporting; Research; Research Personnel; Research Project Grants; Research Proposals; Research Support; Research Training; Resources; Rodent; Running; Sampling; Schools; Scientist; Seasons; Serum; Sleep; Specimen; Susceptibility Gene; Tissue Sample; United States National Institutes of Health; Universities; Wisconsin; Work; Zebrafish; animal colony; base; computerized; data sharing; human DNA; hypocretin; meetings; member; multidisciplinary; neurochemistry; neuropathology; neurotransmission; novel; operation; programs; translational approach; web site

PROJECT A PI: Emmanuel Mignot Title: Research Administration Core, Human DNA Samples Bank, Animal Models, & Databases Description (provided by applicant): A seasoned and well-trained research administration staff is essential for the effective management of a complex multi-disciplinary program project. During the last consecutive 18 years of funding of this program project the Principal Investigator and the Assistant Director of the Sleep Research Center have worked together and built a team of research administrators and research support staff that are responsible for the day-to-day activities of managing the Center for Narcolepsy. This includes budgetary and fiscal reporting planning, oversight of policy and guidelines, animal and human database management, subject recruitment and the integration of this project into the Sleep Research Center and Sleep Clinic, and in general ensuring that the program runs smoothly. To support this revised research proposal, five main core activities are recognized: 1) A research administrative and coordinating function to facilitate the research & interactions among investigators and projects 2) Management of the Stanford University Center for Narcolepsy animal colonies used in this proposal; this includes zebrafish, mice, and rats. 3) Recruitment of human narcolepsy patients for research projects: this includes the banking of DNA, serum, cerebrospinal fluid and brain specimens from narcolepsy and control subjects. 4) Maintenance of computerized databases containing human, mouse/rat, canine narcolepsy data and tissue sample data; maintenance of the project's website and data-sharing on-line. 5) Maintenance of all documentation supporting adherence to all federal guidelines and policies for conducting research. It is the responsibility of the Principal Investigator to assure that the Center for Narcolepsy scientists work as an integrated team. His direction and scientific leadership, is essential to the pursuit of the overall goals of the program. A weekly research meeting is held to facilitate communication among the investigators and between the research staff and research administration staff.

项目A PI：伊曼纽尔·米尼奥 标题：研究管理核心、人类 DNA 样本库、动物模型和数据库 描述（由申请人提供）：经验丰富且训练有素的研究管理人员对于有效管理复杂的多学科项目至关重要。在该项目连续 18 年的资助期间，睡眠研究中心的首席研究员和助理主任共同努力，建立了一个由研究管理人员和研究支持人员组成的团队，负责管理发作性睡病中心的日常活动。这包括预算和财务报告规划、政策和指南监督、动物和人类数据库管理、受试者招募以及将该项目纳入睡眠研究中心和睡眠诊所，并总体上确保该计划顺利运行。为了支这包括斑马鱼、小鼠和大鼠。 3) 为研究项目招募人类嗜睡症患者：这包括储存嗜睡症患者和对照受试者的 DNA、血清、脑脊液和脑标本。 4) 维护包含人类、小鼠/大鼠、犬嗜睡症数据和组织样本数据的计算机化数据库；项目网站的维护和在线数据共享。 5) 维护所有支持遵守所有联邦研究指导方针和政策的文件。首席研究员有责任确保发作性睡病中心的科学家作为一个综合团队开展工作。他的指导和科学领导对于实现该计划的总体目标至关重要。每周举行一次研究会议，以促进研究者之间以及研究人员和研究管理人员之间的沟通。